{"id":"W2807669137","doi":"10.1124/jpet.118.249367","title":"Enhancement of 5-Fluorouracil Cytotoxicity by Pyridoxal 5′-Phosphate and Folinic Acid in Tandem","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research","keywords":"Cytotoxicity; Cofactor; Chemistry; Pyridoxal; Pyridoxal phosphate; Thymidylate synthase; Aminooxyacetic acid; Biochemistry; Stereochemistry; Serine; Enzyme; In vitro; Biology; Fluorouracil","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001488511,0.0002965791,0.0003223775,0.0002012354,0.0002134225,0.0002753707,0.0003522379,0.0004175971,0.001106958],"category_scores_gemma":[0.0002307798,0.0001646015,0.0002075603,0.0002110389,0.0001645434,0.000286241,0.0002138555,0.0003468276,0.0002662422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003199055,"about_ca_system_score_gemma":0.0003910457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002336536,"about_ca_topic_score_gemma":0.002473932,"domain_scores_codex":[0.9998847,0.00001625702,0.00001030276,0.00002692708,0.00003212526,0.00002967923],"domain_scores_gemma":[0.9999335,0.00001799402,0.00001389395,0.000009855556,0.00001149643,0.0000132442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007169081,0.00007145879,0.0001627941,0.00006865764,0.00001165221,0.0000841951,0.00003311405,0.0002320442,0.9933513,0.0001239166,0.00009114685,0.005052913],"study_design_scores_gemma":[0.00002707418,0.0004258528,0.0004799858,0.0000035675,0.00001495833,0.00006463986,0.000009356381,0.00101419,0.9970885,0.00001558861,0.0008518001,0.000004471841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937499,0.00157284,0.00195696,0.0000832811,0.00005173043,0.00004034703,0.0001166337,0.0001294757,0.002298956],"genre_scores_gemma":[0.9961694,0.0006230411,0.001473776,0.00002380077,0.000007478041,0.00001638708,0.00008968759,0.000007935048,0.001588444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002336536,"threshold_uncertainty_score":0.004645944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03462102952352978,"score_gpt":0.3897828331471389,"score_spread":0.3551618036236091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}