{"id":"W2807674644","doi":"10.1016/j.atherosclerosissup.2018.04.180","title":"Functional Analysis of Novel PCSK9 Mutants from Sapiens (R96L, R105W and P174S) and Denisovan (H449L)","year":2018,"lang":"en","type":"article","venue":"Atherosclerosis Supplements","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Homo sapiens; PCSK9; Mutant; Evolutionary biology; Biology; Genetics; Sociology; LDL receptor; Gene; Anthropology; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002774108,0.0007268694,0.0004377993,0.0003168586,0.0002631648,0.0003291916,0.0006875035,0.0005718131,0.002647992],"category_scores_gemma":[0.000234417,0.0002376874,0.0008612354,0.0003406175,0.000527162,0.0001852155,0.0002960991,0.0008686073,0.0008852244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005120709,"about_ca_system_score_gemma":0.0003211673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00267567,"about_ca_topic_score_gemma":0.001798074,"domain_scores_codex":[0.9997353,0.00003381652,0.00005915422,0.0000488382,0.00008105202,0.00004191662],"domain_scores_gemma":[0.9997321,0.00006266576,0.00008987798,0.00002448222,0.00002759447,0.00006320166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006734359,0.00008444877,0.000162679,0.00004231765,0.00003569054,0.0001779137,0.00002486161,0.0001702431,0.9973547,0.0002177708,0.00007480178,0.0009811063],"study_design_scores_gemma":[0.0001800742,0.0003574034,0.00317344,0.000007424204,0.00009194316,0.0006744579,0.00005062237,0.002062194,0.9909737,0.00006087217,0.002346068,0.00002197937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943497,0.0002542082,0.002645441,0.0001469413,0.0001053969,0.00005390585,0.001614771,0.00008270494,0.0007470538],"genre_scores_gemma":[0.9910217,0.0002107351,0.003453537,0.00007975743,0.00001937472,0.00004871454,0.001972143,0.00009801261,0.003096099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00267567,"threshold_uncertainty_score":0.008858442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03977803566980703,"score_gpt":0.2808686343490165,"score_spread":0.2410905986792095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}