{"id":"W2807716352","doi":"10.1002/cpnc.53","title":"Synthesis of Chimeric Oligonucleotides Having Modified Internucleotide Linkages via an Automated H‐Phosphonate/Phosphoramidite Approach","year":2018,"lang":"en","type":"article","venue":"Current Protocols in Nucleic Acid Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phosphoramidate; Phosphoramidite; Oligonucleotide; Phosphonate; Combinatorial chemistry; Solid-phase synthesis; Chemistry; Oligonucleotide synthesis; Nucleic acid; Nucleotide; Stereochemistry; Organic chemistry; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004533277,0.0006812448,0.0007008731,0.0000772869,0.0001497056,0.00008617042,0.001436456,0.0005344793,0.000156768],"category_scores_gemma":[0.0003029434,0.0007073313,0.0002603546,0.0004131513,0.0008309794,0.00004536599,0.00059268,0.0004930013,0.00002006615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009417911,"about_ca_system_score_gemma":0.0001497565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002254583,"about_ca_topic_score_gemma":0.000002067037,"domain_scores_codex":[0.9963759,0.00009167353,0.001045567,0.001256799,0.0004358032,0.000794211],"domain_scores_gemma":[0.9973366,0.0000261727,0.0005812462,0.001479711,0.0002657327,0.0003105522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003054927,0.0009904474,0.003170319,0.0009195656,0.00008012653,0.000005334079,0.0001425859,0.00005728965,0.9784573,0.000006291495,0.0006485533,0.01521671],"study_design_scores_gemma":[0.000981409,0.0001880343,0.001582818,0.0005383071,0.00003929155,0.00003564981,0.0001520868,0.008675019,0.9844975,0.00006040416,0.002494567,0.0007548906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886194,0.0003061698,0.0007027295,0.00001605161,0.0001617426,0.005483621,0.0000662089,0.0002789483,0.004365151],"genre_scores_gemma":[0.9893464,0.00006060145,0.002577045,0.00003495879,0.0004722862,0.007069388,0.0001843279,0.0001424773,0.0001125502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01446182,"threshold_uncertainty_score":0.9995378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01679350779248201,"score_gpt":0.3106297769530226,"score_spread":0.2938362691605406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}