{"id":"W2807736100","doi":"10.1016/j.chom.2018.05.006","title":"The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection","year":2018,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Science Foundation","keywords":"Listeriolysin O; Biology; Endocytosis; Listeria monocytogenes; Cytolysin; Cell biology; Microbiology; Endocytic cycle; Phagosome; Signal transducing adaptor protein; Listeria; Biochemistry; Virulence; Signal transduction; Receptor; Bacteria; Phagocytosis; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001835918,0.0002447205,0.0001644646,0.00006173185,0.0003668617,0.00009802149,0.0002469511,0.0001730533,0.00007103533],"category_scores_gemma":[0.00002677066,0.0002144968,0.0001221116,0.0001671417,0.0001593096,0.00001019335,0.0001041012,0.0001176903,0.0001454322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005878405,"about_ca_system_score_gemma":0.00008851389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001433353,"about_ca_topic_score_gemma":0.0005754043,"domain_scores_codex":[0.9986308,0.00007907388,0.0002999128,0.0004720657,0.0001262377,0.0003919301],"domain_scores_gemma":[0.9991279,0.00001416344,0.0001140616,0.000496415,0.0001045195,0.0001429702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002121757,0.00006682743,0.0009119189,0.00005066293,0.00002548388,0.000008345024,0.0002483071,0.000008136659,0.9981479,0.000001460141,0.0001565722,0.0001621773],"study_design_scores_gemma":[0.0003899447,0.0002250454,0.00483174,0.00002628944,0.00002318579,0.00001993295,0.00002344602,0.00002231455,0.8233216,8.627847e-7,0.1708959,0.0002197811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974144,0.0001590925,0.0005262271,0.000122557,0.0004343063,0.0003993034,0.00006023266,0.00003522845,0.0008486953],"genre_scores_gemma":[0.9936607,0.0005934314,0.0001000755,0.0001874296,0.0004412166,0.00003429386,0.001699497,0.00004005786,0.003243295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1748263,"threshold_uncertainty_score":0.8746926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009869592335198029,"score_gpt":0.2405851252967218,"score_spread":0.2307155329615238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}