{"id":"W2807747793","doi":"10.1097/qad.0000000000001903","title":"Durable suppression of HIV-1 with resistance mutations to integrase inhibitors by dolutegravir following drug washout","year":2018,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Dolutegravir; Integrase; Integrase inhibitor; Virology; Drug resistance; Medicine; Drug; Human immunodeficiency virus (HIV); Pharmacology; HIV drug resistance; Biology; Genetics; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000142799,0.0001665803,0.0002758923,0.0001437982,0.0001218303,0.00001345907,0.00007572281,0.00004361152,0.00009397577],"category_scores_gemma":[0.00006736346,0.0001129528,0.00007425914,0.0004339779,0.00007575554,0.0001076999,0.00002885274,0.00009073214,0.0001280946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000891536,"about_ca_system_score_gemma":0.0001065084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004449775,"about_ca_topic_score_gemma":0.00007364717,"domain_scores_codex":[0.9988945,0.00003038624,0.0002576304,0.000266481,0.0003179957,0.0002330244],"domain_scores_gemma":[0.9993225,0.00006041605,0.00006160466,0.0002756163,0.0001124454,0.0001673776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001035793,0.0007194518,0.2656774,0.000125835,0.000656918,0.0001516779,0.01284136,0.000002634126,0.08673204,0.0003741136,0.6286724,0.003010379],"study_design_scores_gemma":[0.005576944,0.0008151915,0.006598908,0.002386707,0.0006273378,0.00001219785,0.004195471,0.00001995052,0.8755441,0.000201619,0.1035317,0.0004898891],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884421,0.0001410267,0.0005686843,0.002697635,0.0001467495,0.0004017245,0.00002842449,0.00006230413,0.00751131],"genre_scores_gemma":[0.9053472,0.000004899447,0.01553164,0.0001084887,0.000054927,0.00004399159,0.0001214444,0.00002484763,0.07876259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.788812,"threshold_uncertainty_score":0.4606082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006054739560364618,"score_gpt":0.2528910250933006,"score_spread":0.246836285532936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}