{"id":"W2807747793","doi":"10.1097/qad.0000000000001903","title":"Durable suppression of HIV-1 with resistance mutations to integrase inhibitors by dolutegravir following drug washout","year":2018,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Dolutegravir; Integrase; Integrase inhibitor; Virology; Drug resistance; Medicine; Drug; Human immunodeficiency virus (HIV); Pharmacology; HIV drug resistance; Biology; Genetics; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483286,0.0003138898,0.0004747802,0.0001236761,0.0001170935,0.0003683142,0.0003190366,0.0002641568,0.001295553],"category_scores_gemma":[0.0002274327,0.0001436886,0.0002672103,0.000152737,0.0001723284,0.0002079856,0.0001870658,0.0005528748,0.0003678172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002593829,"about_ca_system_score_gemma":0.0001594343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006650371,"about_ca_topic_score_gemma":0.001088341,"domain_scores_codex":[0.9998193,0.00001898857,0.00001770581,0.00005505914,0.00004487778,0.00004398468],"domain_scores_gemma":[0.9998719,0.00002253915,0.00004405475,0.00002729282,0.00001471307,0.00001956469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002561763,0.00008471145,0.0004784529,0.00002649797,0.000009164196,0.00004432376,0.0000161244,0.00009313774,0.9957501,0.00001691696,0.00004855045,0.003175844],"study_design_scores_gemma":[0.00004561111,0.001268905,0.00851614,0.000005823108,0.00001580486,0.000295076,0.00002270379,0.0006632939,0.9874653,0.00001410579,0.001680063,0.000007311515],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976944,0.0006891217,0.0007236591,0.00003368613,0.000012625,0.00002296742,0.0003566831,0.00006765457,0.0003991226],"genre_scores_gemma":[0.9950618,0.0003150788,0.001672534,0.0000569111,0.000008249566,0.00002922734,0.001096043,0.00003220341,0.001727813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001295553,"threshold_uncertainty_score":0.004334092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006054739560364618,"score_gpt":0.2528910250933006,"score_spread":0.246836285532936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}