{"id":"W2807796131","doi":"10.1101/343293","title":"New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Centre for Global Health Research; Université Laval; St. Paul's Hospital; University of British Columbia","funders":"NIHR Nottingham Biomedical Research Centre; NIHR Leicester Biomedical Research Centre; National Heart, Lung, and Blood Institute; NIHR Cambridge Biomedical Research Centre; Economic and Social Research Council; Medical Research Council; Uppsala Universitet; Hjärt-Lungfonden; Centers for Disease Control and Prevention; Ministry of Science and Technology of the People's Republic of China; Wellcome Trust; University of Essex; Cancer Research UK; BHF Centre of Research Excellence, Oxford; Vetenskapsrådet; National Natural Science Foundation of China; Understanding Society; European Commission; British Lung Foundation; Bundesministerium für Bildung und Forschung; NHS Blood and Transplant; National Institute for Health and Care Research; Horizon 2020 Framework Programme; British Heart Foundation; University of Cambridge; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; National Institutes of Health; University of Leicester","keywords":"Pleiotropy; COPD; Phenome; Lung function; Genome-wide association study; Disease; Genetic association; Pulmonary disease; Lung; Genetic variants; Medicine; Multimorbidity; Bioinformatics; Biology; Genome; Genetics; Phenotype; Internal medicine; Genotype; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009268643,0.0003767162,0.0004552178,0.0005821486,0.0002737235,0.0008903451,0.0001955339,0.000484755,0.004171236],"category_scores_gemma":[0.001666772,0.0001589769,0.0004403268,0.0007108702,0.0005773802,0.0003911149,0.0006158301,0.0007021131,0.0002629654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001889278,"about_ca_system_score_gemma":0.0002444788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006595748,"about_ca_topic_score_gemma":0.001004563,"domain_scores_codex":[0.9996194,0.0001292653,0.00002846438,0.0001372762,0.00005352842,0.00003208991],"domain_scores_gemma":[0.999265,0.000325771,0.000176784,0.0001080959,0.00004262542,0.0000817254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003385478,0.0002247268,0.6309117,0.0005844788,0.00173601,0.004555881,0.001513509,0.001588454,0.2549503,0.0100129,0.006232402,0.0843042],"study_design_scores_gemma":[0.0001307401,0.0002476441,0.9554074,0.000109161,0.0007590952,0.00373541,0.000524553,0.00235688,0.01075168,0.01628099,0.009656365,0.00004001995],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793345,0.006012332,0.005872958,0.004149219,0.0001413041,0.000009613776,0.001852707,0.0001028291,0.002524607],"genre_scores_gemma":[0.9933491,0.001331832,0.002848226,0.0004330655,0.0001856537,0.00000987288,0.0004943047,0.00003596779,0.001311904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004171236,"threshold_uncertainty_score":0.0139541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01943564035298158,"score_gpt":0.2629020197234623,"score_spread":0.2434663793704808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}