{"id":"W2807858541","doi":"10.1016/j.stemcr.2018.05.007","title":"Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells","year":2018,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stemcell Technologies","funders":"Vrije Universiteit Brussel","keywords":"Heteroplasmy; Biology; Embryonic stem cell; Genetics; Induced pluripotent stem cell; Somatic cell; Mutagenesis; Mitochondrial DNA; Stem cell; Molecular biology; Cell biology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002253085,0.0001169877,0.0001104482,0.0002983675,0.0001325151,0.0002393226,0.0001134892,0.0001578754,0.0007643907],"category_scores_gemma":[0.0005515392,0.0001154485,0.0001163286,0.0001899265,0.0001491047,0.0001657736,0.0002096569,0.0001811217,0.000183579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009095891,"about_ca_system_score_gemma":0.0001174655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003224211,"about_ca_topic_score_gemma":0.0009481492,"domain_scores_codex":[0.9998398,0.00002343567,0.00002684961,0.00004148825,0.00005318368,0.00001533722],"domain_scores_gemma":[0.9996556,0.0001285389,0.00008231006,0.00004914762,0.00005564249,0.00002872042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004498341,0.000006690984,0.008864047,0.0000284587,0.00001115178,0.0001067146,0.00006442759,0.0001222145,0.9855453,0.0001167778,0.00001298014,0.005076305],"study_design_scores_gemma":[0.000008417234,0.0002573792,0.15606,0.00001997688,0.00008775612,0.001751633,0.0001771914,0.002183606,0.8369997,0.0004173626,0.002024413,0.0000126116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929286,0.0005172935,0.005648551,0.00002109348,0.00000548419,0.00002095185,0.0002303181,0.00002483663,0.0006029912],"genre_scores_gemma":[0.9964645,0.000328373,0.002321384,0.00002088244,0.000003205586,0.00001507295,0.0003609359,0.00002197287,0.000463685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007643907,"threshold_uncertainty_score":0.002557158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01800678086331934,"score_gpt":0.2670648218425488,"score_spread":0.2490580409792295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}