{"id":"W2807858541","doi":"10.1016/j.stemcr.2018.05.007","title":"Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells","year":2018,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stemcell Technologies","funders":"Vrije Universiteit Brussel","keywords":"Heteroplasmy; Biology; Embryonic stem cell; Genetics; Induced pluripotent stem cell; Somatic cell; Mutagenesis; Mitochondrial DNA; Stem cell; Molecular biology; Cell biology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001142014,0.0002854055,0.0003318689,0.00007286334,0.0002169635,0.00006400252,0.00019674,0.0001762913,0.00003814227],"category_scores_gemma":[0.00002019961,0.0001926782,0.00006164386,0.0001872368,0.0002063338,0.000009788659,0.0003402871,0.0001496046,0.00001164729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005876107,"about_ca_system_score_gemma":0.0003455801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006694491,"about_ca_topic_score_gemma":0.0002211784,"domain_scores_codex":[0.9975582,0.000238935,0.0005647148,0.0007254408,0.000423123,0.0004896261],"domain_scores_gemma":[0.9986454,0.00005408746,0.0002549851,0.0007079685,0.000166221,0.0001712899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004450154,0.000125971,0.004181206,0.0002584565,0.00007671662,0.001245478,0.0001765887,0.00001821447,0.9902332,0.000004382599,0.0005367477,0.002697998],"study_design_scores_gemma":[0.003516802,0.001135662,0.005166888,0.0001657778,0.000102537,0.002292102,0.0002488591,0.0006333468,0.9512016,0.00006511447,0.03483053,0.0006408097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953367,0.002671358,0.0001017427,0.0000710863,0.000315661,0.0008068909,0.000006225856,0.00001378199,0.0006765553],"genre_scores_gemma":[0.9841884,0.0006224821,0.00009379481,0.00005971871,0.0001841341,0.00004067535,0.00001635423,0.00004042726,0.01475405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03903166,"threshold_uncertainty_score":0.7857188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01800678086331934,"score_gpt":0.2670648218425488,"score_spread":0.2490580409792295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}