{"id":"W2807901568","doi":"10.1038/s41467-018-04365-8","title":"IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":252,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Mount Sinai Hospital; Hospital for Sick Children; Montreal Heart Institute; University of Toronto; Royal Victoria Hospital; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Walloon excellence in life sciences and biotechnology; Nederlandse Federatie van Universitair Medische Centra; National Cancer Institute; Institut National Du Cancer; Belgian Federal Science Policy Office; National Institute of Diabetes and Digestive and Kidney Diseases; Fonds De La Recherche Scientifique - FNRS; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; RIKEN; Japan Agency for Medical Research and Development","keywords":"Gene; Genetics; Biology; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003622296,0.0001484292,0.000146775,0.0001422604,0.0003845717,0.00003378686,0.000693189,0.0003545678,0.00002399233],"category_scores_gemma":[0.0005159792,0.0001446227,0.00007037009,0.0003474402,0.0004463515,0.00001078366,0.0004065047,0.0006537279,0.00003267758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006621418,"about_ca_system_score_gemma":0.0001045215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001102678,"about_ca_topic_score_gemma":0.004510519,"domain_scores_codex":[0.9985682,0.000478583,0.0002272547,0.0003063215,0.000184265,0.0002353515],"domain_scores_gemma":[0.9978819,0.00007682234,0.0001650756,0.001352256,0.0004466628,0.00007729917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002661056,0.0007199993,0.1811542,0.0000302453,0.0003126044,0.000005222188,0.003154964,0.0004280914,0.7586207,0.003593724,0.006505213,0.04520888],"study_design_scores_gemma":[0.001184162,0.0001636171,0.7573931,0.00003233093,0.00002201225,0.00000670964,0.001477464,0.006284394,0.1382405,0.000858241,0.09389949,0.0004379713],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828061,0.01185461,0.00140827,0.001053626,0.00007846792,0.0004625996,0.00006964208,0.00002947908,0.00223717],"genre_scores_gemma":[0.9897304,0.0009782113,0.00835585,0.0001489098,0.0001141661,0.00007727045,0.00026849,0.00002070215,0.0003060391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6203802,"threshold_uncertainty_score":0.5897542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253458620875133,"score_gpt":0.3358512523015711,"score_spread":0.3133166660928198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}