{"id":"W2807902048","doi":"10.1158/1078-0432.ccr-18-1475","title":"Unexpected Benefits of Aging for Favorable Responses to PD-1 Blockade in Melanoma?","year":2018,"lang":"en","type":"letter","venue":"Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North","funders":"","keywords":"Blockade; Immunosenescence; Melanoma; Immune checkpoint; Cancer; Medicine; Immune system; CD8; PD-L1; Immunotherapy; Cancer research; Oncology; Immunology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001262034,0.000338824,0.0007978327,0.0002090533,0.0005603769,0.0008150777,0.0003844854,0.007189706,0.003815386],"category_scores_gemma":[0.005207957,0.000135652,0.0004401871,0.0001893626,0.0009557556,0.0009789622,0.0002661412,0.006198545,0.002051242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009543925,"about_ca_system_score_gemma":0.0004758863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003074275,"about_ca_topic_score_gemma":0.0006580938,"domain_scores_codex":[0.9995271,0.0001744142,0.00004563999,0.00007807236,0.00008833168,0.00008654854],"domain_scores_gemma":[0.9979774,0.001274633,0.0001478249,0.0001364155,0.0002274632,0.0002361616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003607782,0.0005157904,0.01989559,0.000526503,0.000109389,0.05628029,0.000267486,0.0005930464,0.01091859,0.01775298,0.6720588,0.2174737],"study_design_scores_gemma":[0.003106945,0.002598229,0.05539112,0.0008290661,0.000255807,0.07759577,0.0007926984,0.003190019,0.005688681,0.0627317,0.7876899,0.0001301209],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03846071,0.01629361,0.0005562527,0.9204516,0.01118548,0.00004031222,0.0002327833,0.0001445912,0.01263468],"genre_scores_gemma":[0.3754539,0.01406014,0.001021569,0.4635347,0.1349743,0.0001514977,0.0001720808,0.00007134943,0.01056045],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.007189706,"threshold_uncertainty_score":0.01276374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3077727104335035,"score_gpt":0.5352811957631706,"score_spread":0.2275084853296671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}