{"id":"W2807921644","doi":"10.1534/genetics.117.300515","title":"The Spectrum of Replication Errors in the Absence of Error Correction Assayed Across the Whole Genome of <i>Escherichia coli</i>","year":2018,"lang":"en","type":"article","venue":"Genetics","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of General Medical Sciences; Army Research Office; Multidisciplinary University Research Initiative; National Institutes of Health","keywords":"Proofreading; Biology; Genetics; DNA mismatch repair; DNA replication; Mutation rate; DNA polymerase; Mutation; DNA polymerase I; Mutation Accumulation; Chromosome; Polymerase; SOS response; DNA repair; DNA; Gene; Polymerase chain reaction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003572323,0.0003496004,0.0003967018,0.0008595134,0.0001611357,0.0004742949,0.000300937,0.0004294114,0.0006081759],"category_scores_gemma":[0.0007804976,0.000263091,0.0002508656,0.0005967157,0.0002491741,0.0002947373,0.0003381182,0.0004682064,0.000205195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464123,"about_ca_system_score_gemma":0.0001034752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001141586,"about_ca_topic_score_gemma":0.0008947214,"domain_scores_codex":[0.9995483,0.00006649953,0.0000490204,0.0001252932,0.0001449523,0.00006600878],"domain_scores_gemma":[0.9989606,0.0002221884,0.0002696951,0.0001266657,0.0002746152,0.0001462143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001160364,0.00003258293,0.004356354,0.00003039673,0.00002984078,0.00002872495,0.00002335787,0.0001667865,0.9934907,0.00003481299,0.0000386224,0.001651679],"study_design_scores_gemma":[0.000005988151,0.0006341835,0.1847938,0.00001391082,0.00008662853,0.0006294427,0.000150413,0.002412696,0.8101109,0.0001120113,0.001023477,0.00002654631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995932,0.0004009793,0.00223191,0.00003755259,0.000009319148,0.0000112116,0.0008093113,0.00008278665,0.0004849715],"genre_scores_gemma":[0.9948732,0.000215363,0.002667895,0.00006555297,0.000005161527,0.00001863994,0.001658539,0.00004600867,0.0004495443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001141586,"threshold_uncertainty_score":0.002269924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219917816297543,"score_gpt":0.2835148665001775,"score_spread":0.271315688337202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}