{"id":"W2807944903","doi":"10.3390/cancers10060205","title":"Oncolytic Reovirus and Immune Checkpoint Inhibition as a Novel Immunotherapeutic Strategy for Breast Cancer","year":2018,"lang":"en","type":"article","venue":"Cancers","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Calgary Laboratory Services; University of New Brunswick; University of Calgary","funders":"Alberta Innovates","keywords":"Oncolytic virus; Immune system; Immune checkpoint; Cancer research; Breast cancer; Cancer immunotherapy; Immunotherapy; Medicine; Cancer; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001658918,0.0002855011,0.0002461214,0.0001944251,0.00006534433,0.0003237836,0.0002201806,0.0003303589,0.0004558151],"category_scores_gemma":[0.00006558642,0.0001058756,0.0002496487,0.0001025389,0.0001637536,0.0002623934,0.0001556325,0.0005848255,0.0001562548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002855345,"about_ca_system_score_gemma":0.0001732432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002638142,"about_ca_topic_score_gemma":0.0005935537,"domain_scores_codex":[0.9999034,0.00002006657,0.000004868101,0.00001687108,0.00002277669,0.00003197715],"domain_scores_gemma":[0.9999707,0.000005168418,0.000009673333,0.000004903301,0.000003187816,0.000006364439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000259044,0.0002037051,0.0001839971,0.0001433632,0.00001432981,0.00006253789,0.00002086742,0.0005416677,0.9804218,0.0007382688,0.000153286,0.01725712],"study_design_scores_gemma":[0.0001192067,0.003248228,0.001658219,0.00003804114,0.00004883639,0.0007477748,0.00002802395,0.002443726,0.9744768,0.0002498262,0.01692976,0.00001154587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9305785,0.04419814,0.01870051,0.0006979301,0.0002222527,0.0002098443,0.000241471,0.0001869672,0.004964396],"genre_scores_gemma":[0.9777501,0.01094477,0.007951,0.0001586315,0.00004304334,0.00008225537,0.00020627,0.00002012013,0.002843925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004558151,"threshold_uncertainty_score":0.002071738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03031830255682979,"score_gpt":0.3397396547546556,"score_spread":0.3094213521978258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}