{"id":"W2807985734","doi":"10.1016/j.cell.2018.05.036","title":"Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":379,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Human Genome Research Institute; Fund for Innovation in Cancer Informatics; Gerstner Family Foundation; American Cancer Society; Kreftforeningen; American Association for Cancer Research; Prostate Cancer Foundation; Movember Foundation; National Institutes of Health; Canadian Institutes of Health Research; U.S. Department of Defense","keywords":"Biology; Prostate cancer; Chromoplexy; Whole genome sequencing; Genome; Gene duplication; Genetics; Gene; Context (archaeology); Enhancer; Tandem exon duplication; Computational biology; Cancer; Cancer research; PCA3; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001943589,0.0002398398,0.0002456134,0.0004590649,0.000258914,0.0005915288,0.0003205573,0.0005169533,0.002178559],"category_scores_gemma":[0.0006418475,0.0001829038,0.0003630627,0.0004562202,0.0003107156,0.0001888225,0.0002726998,0.0006979576,0.0004137659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004150358,"about_ca_system_score_gemma":0.0003252113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002552667,"about_ca_topic_score_gemma":0.006202397,"domain_scores_codex":[0.9998022,0.00002054427,0.000009899134,0.00006202704,0.00007608784,0.0000293644],"domain_scores_gemma":[0.999778,0.00005767038,0.00006520436,0.00003896216,0.00002760942,0.0000325076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004974259,0.00005357096,0.01453552,0.000115735,0.000184304,0.0008787146,0.0001263291,0.001790443,0.9642656,0.001276387,0.0007669484,0.01550907],"study_design_scores_gemma":[0.00009799277,0.0007287377,0.3484323,0.00007158441,0.0007681656,0.006811411,0.0003943088,0.01699323,0.58876,0.003957146,0.03289302,0.0000921133],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843242,0.001650482,0.006772267,0.000434936,0.00007879482,0.00003459114,0.003993889,0.0003328808,0.002377963],"genre_scores_gemma":[0.9914186,0.0005902816,0.003882604,0.0002569766,0.00001770558,0.00001336342,0.002395052,0.0001060592,0.001319257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002552667,"threshold_uncertainty_score":0.007287979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03326346661096351,"score_gpt":0.3218360725124005,"score_spread":0.288572605901437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}