{"id":"W2808040230","doi":"10.1158/1541-7786.mcr-17-0681","title":"S1P Stimulates Proliferation by Upregulating CTGF Expression through S1PR2-Mediated YAP Activation","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Johns Hopkins University; Canadian Institutes of Health Research; American Association for Cancer Research","keywords":"CTGF; Hippo signaling pathway; Cell growth; Downregulation and upregulation; Cell biology; Cancer research; Biology; Gene knockdown; Signal transduction; Growth factor; Receptor; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006032761,0.0002016355,0.0001553095,0.00008011286,0.0004156723,0.0001089713,0.0002732495,0.0002752468,0.0001102894],"category_scores_gemma":[0.0003957136,0.0001909708,0.00006856918,0.0003489746,0.000222966,0.00002076584,0.0001704702,0.0002810821,0.00004722774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007155447,"about_ca_system_score_gemma":0.0002222603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002269534,"about_ca_topic_score_gemma":0.00001792352,"domain_scores_codex":[0.9975071,0.0003683416,0.0002604206,0.000635705,0.0006639026,0.0005645094],"domain_scores_gemma":[0.9986324,0.00003557454,0.00008327744,0.0004633121,0.0006642722,0.0001211794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001802233,0.00005889963,0.0004957071,0.00002632006,0.00003239757,0.000002697159,0.0002704374,0.0002581228,0.9941412,0.00002784506,0.002884291,0.001621919],"study_design_scores_gemma":[0.0005613741,0.0004009393,0.00008707584,0.0001043877,0.000005756345,0.000001562318,0.00006004789,0.0009386691,0.977455,0.0002431808,0.01992127,0.0002207241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853883,0.000878585,0.01143792,0.000448304,0.00009829299,0.0004877756,0.00003319958,0.00004391795,0.001183728],"genre_scores_gemma":[0.9969037,0.00008846215,0.0008349613,0.000279618,0.0004283451,0.000201278,0.000493957,0.00005910679,0.0007105571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01703697,"threshold_uncertainty_score":0.7787564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04596475383822941,"score_gpt":0.3849844331743165,"score_spread":0.3390196793360871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}