{"id":"W2808047733","doi":"10.1186/s13063-018-2720-6","title":"A phase IIa proof-of-concept, placebo-controlled, randomized, double-blind, crossover, single-dose clinical trial of a new class of bronchodilator for acute asthma","year":2018,"lang":"en","type":"article","venue":"Trials","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Energy; University of Calgary","funders":"Alberta Innovates - Health Solutions; Calgary Laboratory Services; University of Calgary; Pfizer","keywords":"Medicine; Bronchodilator; Tolerability; Bronchoconstriction; Asthma; Crossover study; Placebo; Spirometry; Anesthesia; Adverse effect; Bronchodilator Agents; Inhalation; Randomized controlled trial; Allergen; Internal medicine; Allergy; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003330476,0.002766684,0.003663342,0.0006876905,0.0009303085,0.001260162,0.0012323,0.003216741,0.006124569],"category_scores_gemma":[0.002040348,0.001097036,0.001465943,0.0005397731,0.001896012,0.001344372,0.0004132856,0.003373748,0.001436236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006372842,"about_ca_system_score_gemma":0.002031795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004318052,"about_ca_topic_score_gemma":0.0009588142,"domain_scores_codex":[0.9989604,0.0005102131,0.00006918975,0.000176923,0.000117865,0.0001653592],"domain_scores_gemma":[0.9988382,0.0002570066,0.0002790118,0.0001356808,0.0001337981,0.0003562141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.92414,0.03513128,0.0003422738,0.0008896622,0.0003715151,0.00005984121,0.00008960813,0.0004008632,0.0209373,0.0002413188,0.001188728,0.01620764],"study_design_scores_gemma":[0.8182404,0.1788839,0.0004922979,0.00001974006,0.0001001697,0.00002510384,0.00001135005,0.0002186392,0.001164789,0.00008810408,0.0007441315,0.00001139949],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9352015,0.004546672,0.004751635,0.001171862,0.001378232,0.04668766,0.002444819,0.000485066,0.003332473],"genre_scores_gemma":[0.9069316,0.004547463,0.01225807,0.003143821,0.001805727,0.05933783,0.003459787,0.0001183408,0.008397361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006124569,"threshold_uncertainty_score":0.02048868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3395700799792805,"score_gpt":0.5497289902983158,"score_spread":0.2101589103190353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}