{"id":"W2808127185","doi":"10.3747/co.25.3942","title":"The Evolution of Biosimilars in Oncology, with a Focus on Trastuzumab","year":2018,"lang":"en","type":"review","venue":"Current Oncology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Calgary","funders":"","keywords":"Biosimilar; Trastuzumab; Medicine; Breast cancer; Metastatic breast cancer; Disease; Oncology; Human Epidermal Growth Factor Receptor 2; Cancer; Intensive care medicine; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001561926,0.0005351105,0.00241064,0.0003793568,0.0001695698,0.000008745294,0.0007413793,0.001569766,0.0001283052],"category_scores_gemma":[0.000335641,0.0002768333,0.0004584635,0.0006674774,0.001976738,0.00002563302,0.0001765967,0.001626868,0.0001353717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001727266,"about_ca_system_score_gemma":0.001625054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002096326,"about_ca_topic_score_gemma":0.0004292516,"domain_scores_codex":[0.9949302,0.002466174,0.001147765,0.0006822714,0.00007537488,0.0006982346],"domain_scores_gemma":[0.9958417,0.002494212,0.0008755272,0.0005995017,0.0001412986,0.00004771811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003061102,0.000841254,0.00002259484,0.00081901,0.0003089696,0.000008649438,0.00004454688,4.733999e-8,0.000005503436,0.002023174,0.01005483,0.9855653],"study_design_scores_gemma":[0.001059159,0.004848873,0.00003243788,0.003577931,0.0007644881,0.0001196234,0.00009859957,0.000001061257,0.00003048516,0.000472015,0.9886944,0.0003009848],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001772856,0.9915064,0.00008764832,0.0005750115,0.002604093,0.001018049,0.0001014614,0.0000274076,0.004062226],"genre_scores_gemma":[0.0002063679,0.9990039,0.0001511357,0.00003513841,0.0001408467,0.000193293,0.00003709679,0.00003533796,0.0001969179],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9852643,"threshold_uncertainty_score":0.9999684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1440858940537858,"score_gpt":0.4479765895032554,"score_spread":0.3038906954494696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}