{"id":"W2808207128","doi":"10.1172/jci97116","title":"Inherited p40phox deficiency differs from classic chronic granulomatous disease","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"NHLBI Division of Intramural Research; National Center for Research Resources; National Cancer Institute; Canadian Institutes of Health Research; National Center for Advancing Translational Sciences; Consejo Nacional de Ciencia y Tecnología; Agence Nationale de la Recherche; National Institutes of Health; U.S. Department of Health and Human Services; Japan Foundation for Pediatric Research; Lastentautien Tutkimussäätiö; Institut des maladies génétiques Imagine; Leona M. and Harry B. Helmsley Charitable Trust; Institut National de la Santé et de la Recherche Médicale; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; Université Paris Descartes; St. Giles Foundation; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","keywords":"Chronic granulomatous disease; NADPH oxidase; Compound heterozygosity; Biology; Oxidase test; Aspergillus fumigatus; Phagocyte; Immunology; Mutation; Candida albicans; Microbiology; Gene; Phagocytosis; Genetics; Enzyme; Reactive oxygen species; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007534201,0.0001881095,0.0005075096,0.0001260221,0.0001777831,0.0000286023,0.0003166224,0.0002592842,0.0004882333],"category_scores_gemma":[0.0009625483,0.0001422407,0.0002693877,0.0002102613,0.0009444727,0.0002621034,0.00005928864,0.0006078703,0.0003963293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006257784,"about_ca_system_score_gemma":0.0004006078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002112562,"about_ca_topic_score_gemma":0.00001328531,"domain_scores_codex":[0.9973328,0.0006576768,0.001364318,0.000267262,0.0001142069,0.0002637703],"domain_scores_gemma":[0.9977825,0.0004580542,0.0009665458,0.0002621985,0.0003492808,0.0001814656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000822276,0.0003416115,0.03809167,0.00002114606,0.0002330466,0.00006103492,0.0002327837,0.000004676177,0.9347849,0.001448759,0.00686935,0.0170887],"study_design_scores_gemma":[0.006730485,0.0038302,0.6704528,0.0004760716,0.000490276,0.00005618099,0.0001194007,0.0001166209,0.2520804,0.04572162,0.01939916,0.0005268781],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932449,0.001396933,0.001265747,0.001264773,0.00253892,0.0001285207,0.00002314517,0.00003159522,0.0001054875],"genre_scores_gemma":[0.996919,0.0001767795,0.0005043859,0.001248955,0.0009091432,0.00000308443,0.00004708863,0.00001922467,0.0001723348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6827046,"threshold_uncertainty_score":0.5800407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05577987491519491,"score_gpt":0.3287580882557917,"score_spread":0.2729782133405968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}