{"id":"W2808221505","doi":"10.21037/amj.2018.06.02","title":"Does increased expression of glucocorticoid receptor support application of antagonists to this receptor for the treatment of castration resistant prostate cancer?","year":2018,"lang":"en","type":"letter","venue":"AME Medical Journal","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia","funders":"National Cancer Institute","keywords":"Prostate cancer; Glucocorticoid receptor; Androgen receptor; Medicine; Receptor; Cancer research; Glucocorticoid; Internal medicine; Androgen deprivation therapy; Endocrinology; Receptor expression; Cancer; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007963713,0.0002494289,0.0007845773,0.0003267116,0.0007481324,0.0009011517,0.0007358677,0.01214176,0.003869685],"category_scores_gemma":[0.0066315,0.0001668224,0.0005589011,0.0003109501,0.001327932,0.001457371,0.0003338232,0.007504072,0.00317457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001191611,"about_ca_system_score_gemma":0.0007877245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005435945,"about_ca_topic_score_gemma":0.001032882,"domain_scores_codex":[0.9995306,0.0001369897,0.00007775061,0.00004709103,0.0001325148,0.00007511911],"domain_scores_gemma":[0.9981089,0.001030547,0.0002279742,0.00009217625,0.0003388066,0.0002015522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005692279,0.0002776996,0.02284645,0.0006985478,0.00009005901,0.2119835,0.0004629935,0.0004289989,0.004851654,0.01607869,0.5903686,0.1513434],"study_design_scores_gemma":[0.0003778776,0.0005481892,0.01080631,0.0006460742,0.00009318936,0.1998772,0.001148633,0.001147538,0.001793918,0.03090749,0.7525691,0.00008459133],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.009081005,0.01283203,0.0003788179,0.9579009,0.01117819,0.00002212875,0.00005638409,0.00003763997,0.008512927],"genre_scores_gemma":[0.1482435,0.02250851,0.001043843,0.6276928,0.1924219,0.00004747924,0.0001291142,0.00003236803,0.007880392],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01214176,"threshold_uncertainty_score":0.01294535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02031337899748133,"score_gpt":0.3411111499477578,"score_spread":0.3207977709502765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}