{"id":"W2808271763","doi":"10.1111/dom.13353","title":"Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline <scp>BMI</scp> or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials","year":2018,"lang":"en","type":"article","venue":"Diabetes Obesity and Metabolism","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"ExxonMobil Research and Engineering Company; Novo Nordisk","keywords":"Semaglutide; Nausea; Weight loss; Vomiting; Medicine; Sitagliptin; Type 2 diabetes; Placebo; Internal medicine; Dulaglutide; Adverse effect; Gastroenterology; Exenatide; Liraglutide; Diabetes mellitus; Obesity; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002068177,0.0007310598,0.001740739,0.0003023213,0.0002281592,0.0007530528,0.0004083143,0.0007907516,0.003287664],"category_scores_gemma":[0.002222579,0.0003284646,0.002373247,0.0003858655,0.0003593671,0.0004878174,0.0002769022,0.001004984,0.0002441327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003364967,"about_ca_system_score_gemma":0.0005187545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005429097,"about_ca_topic_score_gemma":0.002290384,"domain_scores_codex":[0.9991986,0.0004550321,0.0001367938,0.00006646746,0.00008350678,0.00005962277],"domain_scores_gemma":[0.999243,0.000237755,0.0002940655,0.00005136593,0.00006796895,0.0001056999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8871437,0.002670988,0.008404975,0.007350313,0.01100938,0.0001624654,0.0001546978,0.0004452919,0.006627488,0.0002536076,0.001887118,0.07389002],"study_design_scores_gemma":[0.7615791,0.1794884,0.03794185,0.0009989676,0.0118778,0.0004003745,0.0001525649,0.0007370865,0.002576804,0.0005024993,0.003704866,0.00003964895],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563434,0.03696408,0.0005063607,0.0006061812,0.0003003956,0.001234462,0.0006342869,0.0001247979,0.003286104],"genre_scores_gemma":[0.9885038,0.008155229,0.0006047836,0.0005109365,0.0002153708,0.0007011579,0.0006090723,0.00001001858,0.0006895525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003287664,"threshold_uncertainty_score":0.01099837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01985558255236574,"score_gpt":0.2665220678581215,"score_spread":0.2466664853057557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}