{"id":"W2808289287","doi":"10.1074/jbc.ra117.001171","title":"Prion gene paralogs are dispensable for early zebrafish development and have nonadditive roles in seizure susceptibility","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Alberta Innovates Bio Solutions; Alberta Innovates - Health Solutions; Alzheimer Society","keywords":"Zebrafish; Biology; Phenotype; Mutant; Genetics; Gene; Loss function; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001877337,0.0006100316,0.0003166273,0.0006932899,0.0002648742,0.0002778995,0.0004107648,0.0005513146,0.002724409],"category_scores_gemma":[0.0002795527,0.0003874085,0.0004013398,0.0001875642,0.0007273732,0.0002789097,0.0003666104,0.0009678543,0.0006510371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000411208,"about_ca_system_score_gemma":0.0005647084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001675623,"about_ca_topic_score_gemma":0.006745389,"domain_scores_codex":[0.9997056,0.00002378822,0.00004726239,0.00006215238,0.0001108807,0.0000503153],"domain_scores_gemma":[0.999472,0.00009861737,0.000172017,0.00007015202,0.00004105299,0.0001461932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004904442,0.000009967543,0.0002275382,0.00002229439,0.000005389684,0.0002919108,0.00001578978,0.00004720668,0.9986093,0.0001148327,0.00002261895,0.0005841427],"study_design_scores_gemma":[0.00005458318,0.0002539825,0.02480409,0.00002033246,0.0000748458,0.002247459,0.0001064457,0.001531798,0.9679785,0.0002015102,0.002700765,0.00002560185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937888,0.0006026314,0.003254149,0.0001050525,0.00003684737,0.00002055288,0.0004962602,0.0001891548,0.001506608],"genre_scores_gemma":[0.9900048,0.0003875115,0.003056988,0.00007546686,0.000006986092,0.00004069175,0.0005083484,0.000113884,0.005805256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002724409,"threshold_uncertainty_score":0.009114027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029608239494701,"score_gpt":0.2629841325134004,"score_spread":0.2426880501184534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}