{"id":"W2808372703","doi":"10.1093/cid/ciy505","title":"Immediate Versus Deferred Switching From a Boosted Protease Inhibitor–based Regimen to a Dolutegravir-based Regimen in Virologically Suppressed Patients With High Cardiovascular Risk or Age ≥50 Years: Final 96-Week Results of the NEAT022 Study","year":2018,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"European Regional Development Fund; Astellas Pharma; ViiV Healthcare; Instituto de Salud Carlos III; National Institute for Health and Care Research; Gilead Sciences","keywords":"Regimen; Dolutegravir; Medicine; Ritonavir; Adverse effect; Internal medicine; Randomized controlled trial; Confidence interval; Intention-to-treat analysis; Gastroenterology; Viral load; Surgery; Human immunodeficiency virus (HIV); Immunology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003409388,0.001004386,0.001755176,0.0002361847,0.000240857,0.0009514713,0.0008590671,0.0009134515,0.002701805],"category_scores_gemma":[0.002907065,0.0006198005,0.001905175,0.0002516182,0.0008492032,0.0007812012,0.0003861937,0.002312528,0.0004177916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000689013,"about_ca_system_score_gemma":0.000849151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006153704,"about_ca_topic_score_gemma":0.001489334,"domain_scores_codex":[0.9987311,0.000773082,0.0001120706,0.0001621346,0.0001163046,0.0001053991],"domain_scores_gemma":[0.9977984,0.0007236185,0.0006168924,0.0002041749,0.0001056898,0.0005512317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9721286,0.007684605,0.002365875,0.0002175743,0.0007785973,0.00002433826,0.00005490693,0.0004009223,0.001651579,0.00003791612,0.0002575436,0.01439738],"study_design_scores_gemma":[0.794571,0.1941653,0.008521823,0.00004100748,0.0008601706,0.00004873758,0.00003026783,0.0005491571,0.0006014134,0.0000898161,0.0005007875,0.00002050044],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967741,0.001271744,0.0001928263,0.000151406,0.00008743023,0.0004544444,0.0003373431,0.00001588701,0.000714732],"genre_scores_gemma":[0.995977,0.0008092417,0.000738673,0.0003226549,0.0001845369,0.0004577678,0.0005734231,0.000007251543,0.0009294775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003409388,"threshold_uncertainty_score":0.01803076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04910471173106699,"score_gpt":0.3338250838023796,"score_spread":0.2847203720713126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}