{"id":"W2808400246","doi":"10.1016/j.vph.2018.06.006","title":"Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress","year":2018,"lang":"en","type":"article","venue":"Vascular Pharmacology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"NADPH oxidase; Endothelial dysfunction; Vasodilation; Endocrinology; Internal medicine; Oxidative stress; Protein kinase C; Biology; Pharmacology; Kinase; Chemistry; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003165673,0.0005523539,0.0007165116,0.0001578818,0.0002740345,0.0006161841,0.0004487958,0.0003605137,0.002321199],"category_scores_gemma":[0.0001720842,0.0002831268,0.0004603994,0.0001860623,0.0003268923,0.0005884003,0.0002594181,0.001564593,0.0002835774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002486195,"about_ca_system_score_gemma":0.0003498532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006294693,"about_ca_topic_score_gemma":0.001182736,"domain_scores_codex":[0.9998658,0.00002692508,0.00001117598,0.00002278557,0.00001662985,0.00005657473],"domain_scores_gemma":[0.9999115,0.00000755581,0.00002748993,0.00001109292,0.000008453686,0.00003378061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02324874,0.002505209,0.001209383,0.0005350663,0.0002740367,0.0003337125,0.0001188477,0.0003869254,0.9342805,0.001352136,0.001532329,0.03422325],"study_design_scores_gemma":[0.003775595,0.01248767,0.03475348,0.00004936828,0.000702736,0.0008645027,0.0002636464,0.004263982,0.9273714,0.0006985111,0.01469972,0.00006924948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856818,0.005723477,0.004906758,0.0007640885,0.0002974276,0.00009965114,0.0002208314,0.0002710016,0.002034969],"genre_scores_gemma":[0.9913629,0.003048686,0.002709659,0.0002028515,0.0001141707,0.00009128037,0.0002262458,0.00003426058,0.002209793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002321199,"threshold_uncertainty_score":0.007765234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120059473294708,"score_gpt":0.2804705403223756,"score_spread":0.2684645929929048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}