{"id":"W2808408793","doi":"10.4049/jimmunol.1800180","title":"Myeloid-Derived Suppressor Cells Contribute to Susceptibility to <i>Trypanosoma congolense</i> Infection by Suppressing CD4+ T Cell Proliferation and IFN-γ Production","year":2018,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Arginase; Biology; Parasitemia; Immunology; T cell; Myeloid-derived Suppressor Cell; Spleen; Immune system; Bone marrow; Trypanosoma; Myeloid; Haematopoiesis; Suppressor; Stem cell; Virology; Cell biology; Arginine; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009237946,0.0004014734,0.0002001775,0.0002250588,0.000118048,0.0002458732,0.0001172476,0.0001984317,0.001312448],"category_scores_gemma":[0.00008905349,0.00008741109,0.0001763849,0.00006157927,0.000246035,0.0001304143,0.0001340795,0.0004293374,0.0003214185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001538752,"about_ca_system_score_gemma":0.0000934781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002593666,"about_ca_topic_score_gemma":0.0002519039,"domain_scores_codex":[0.9999248,0.00001821364,0.000009069316,0.00001143518,0.00001410692,0.00002240537],"domain_scores_gemma":[0.9999105,0.00000951705,0.00003287604,0.000007287059,0.000007934067,0.00003181989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002754662,0.00002753617,0.0007098049,0.00004509982,0.000004301499,0.00008061632,0.00001129569,0.00004096083,0.9977457,0.00005891411,0.00005824817,0.0009421507],"study_design_scores_gemma":[0.0000777598,0.0008550422,0.0192119,0.00001695128,0.00003939232,0.0008885256,0.0000970833,0.001062067,0.9726496,0.0001351189,0.004959197,0.000007263334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944369,0.001857628,0.001748233,0.0001915113,0.00004051942,0.00004280095,0.0004190448,0.0001179642,0.00114536],"genre_scores_gemma":[0.9977767,0.0004382821,0.000484313,0.00004485205,0.00003088645,0.00002473793,0.0002720159,0.000009889486,0.0009181995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001312448,"threshold_uncertainty_score":0.004390538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007345813254940889,"score_gpt":0.2326256749889375,"score_spread":0.2252798617339966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}