{"id":"W2808508683","doi":"10.1016/j.hrthm.2018.06.014","title":"Application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling","year":2018,"lang":"en","type":"article","venue":"Heart Rhythm","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Montreal Heart Institute","funders":"","keywords":"Kinome; Medicine; Kinase; Protein kinase B; Atrial fibrillation; Phosphorylation; Proto-oncogene tyrosine-protein kinase Src; Cancer research; Internal medicine; Cell biology; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001237136,0.0000553152,0.0001120289,0.0001029153,0.00003328573,0.000007187251,0.00003073051,0.00005364492,0.000009903847],"category_scores_gemma":[0.00004430622,0.00006013878,0.0001381894,0.0001624685,0.00000868527,0.000002981328,0.00001782032,0.0000178843,0.000005964673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001214992,"about_ca_system_score_gemma":0.00001865779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001186974,"about_ca_topic_score_gemma":0.000258606,"domain_scores_codex":[0.9994596,0.00001569304,0.0001875166,0.0001973266,0.00004490811,0.00009496613],"domain_scores_gemma":[0.9996031,0.000009634673,0.00005254066,0.0002062044,0.00009957804,0.00002897747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001428132,0.000005953957,0.0004542041,0.000003760889,0.00005007349,2.55198e-8,0.00002231181,0.003377908,0.9929482,0.0000862509,0.0001798366,0.002728608],"study_design_scores_gemma":[0.0004391978,0.0003829205,0.001471766,0.000009943477,0.00009135389,0.00001029238,0.00002391702,0.0825451,0.8447697,0.0002197197,0.06988262,0.0001535167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6868952,0.00005576733,0.3126018,0.00009834885,0.00007518799,0.0002080679,0.00002170155,0.000002943593,0.00004093962],"genre_scores_gemma":[0.9930359,0.00001208158,0.005743349,0.00005333759,0.0008713457,0.000008378528,0.0002156295,0.000008150051,0.0000518503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3068585,"threshold_uncertainty_score":0.2452388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01727011879682573,"score_gpt":0.2990566247480494,"score_spread":0.2817865059512237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}