{"id":"W2808562501","doi":"10.1038/s41409-018-0261-y","title":"Final outcomes of escalated melphalan 280 mg/m2 with amifostine cytoprotection followed autologous hematopoietic stem cell transplantation for multiple myeloma: high CR and VGPR rates do not translate into improved survival","year":2018,"lang":"en","type":"article","venue":"Bone Marrow Transplantation","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Melphalan; Medicine; Amifostine; Multiple myeloma; Internal medicine; Oncology; Autologous stem-cell transplantation; Transplantation; Chemotherapy; Hematopoietic stem cell transplantation; Surgery; Urology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006416824,0.0004036349,0.001229909,0.0002323297,0.0002622118,0.0007491547,0.0004456088,0.0004618865,0.002151423],"category_scores_gemma":[0.0009238261,0.0001134654,0.001357868,0.0002912729,0.0003003419,0.0006522528,0.0003976052,0.001252124,0.000465065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008640601,"about_ca_system_score_gemma":0.0005547225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007803947,"about_ca_topic_score_gemma":0.001522095,"domain_scores_codex":[0.999611,0.00008307242,0.00003133517,0.00006639882,0.00006118866,0.000147124],"domain_scores_gemma":[0.9995341,0.00009168522,0.0001149819,0.00005790003,0.00002912451,0.000172238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3887332,0.01018703,0.08072902,0.0004001924,0.003689547,0.001544485,0.0002640556,0.01229746,0.0294688,0.001221047,0.004037098,0.467428],"study_design_scores_gemma":[0.02135434,0.3224851,0.6057301,0.000292778,0.00482093,0.003458611,0.0003236902,0.007751676,0.02111811,0.003716415,0.008813386,0.0001349695],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945984,0.001913454,0.0005785144,0.0002284594,0.00007034795,0.0000978832,0.0005095422,0.0000379231,0.001965429],"genre_scores_gemma":[0.9978595,0.0003351633,0.0002167883,0.0002281693,0.00003506148,0.00004020086,0.0008030031,0.00001073951,0.0004713098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002151423,"threshold_uncertainty_score":0.007197261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01922191573247355,"score_gpt":0.2795419795224154,"score_spread":0.2603200637899419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}