{"id":"W2808586822","doi":"10.3747/co.25.3796","title":"Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors, T790M, and Clinical Trials","year":2018,"lang":"en","type":"review","venue":"Current Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Peking University; Peking University People's Hospital; National Natural Science Foundation of China","keywords":"T790M; Medicine; Tyrosine kinase; Epidermal growth factor receptor; Cancer research; Clinical trial; Pharmacology; Receptor; Bioinformatics; Oncology; Internal medicine; Biology; Gefitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001351194,0.0005307042,0.001351538,0.001699797,0.00023002,0.0009601698,0.0009387293,0.001198644,0.003858786],"category_scores_gemma":[0.003133395,0.0002129809,0.0008763699,0.001787129,0.000369007,0.001035871,0.0004735322,0.001518559,0.001003718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007117314,"about_ca_system_score_gemma":0.001568903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007627226,"about_ca_topic_score_gemma":0.001787042,"domain_scores_codex":[0.9994903,0.0001308069,0.0001101,0.00006533858,0.0001733664,0.00003016663],"domain_scores_gemma":[0.998768,0.0007722036,0.0001614935,0.00002436463,0.0002235546,0.00005035289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001263209,0.000042699,0.0001934546,0.04346116,0.0002012041,0.0001371386,0.00006407399,0.0002678824,0.00059737,0.002759427,0.04329257,0.9088567],"study_design_scores_gemma":[0.00006776629,0.0001349327,0.001046268,0.02614006,0.0004340777,0.00113723,0.00005849055,0.0001003168,0.000262346,0.00201224,0.9685879,0.00001837469],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008412202,0.9986157,0.0000499641,0.0003821916,0.0001402766,0.000007145878,0.00001978242,0.00000365348,0.0006971909],"genre_scores_gemma":[0.0007047859,0.9982979,0.0001104817,0.0004379831,0.0001325693,0.00001140933,0.00003517889,0.000001450453,0.0002681791],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003858786,"threshold_uncertainty_score":0.01290888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3280255419870526,"score_gpt":0.5794213739787181,"score_spread":0.2513958319916655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}