{"id":"W2808591932","doi":"10.1038/s41467-018-04758-9","title":"A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; amfAR, The Foundation for AIDS Research; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Gp41; Virology; Antibody; Heterologous; Trimer; Glycoprotein; Simian immunodeficiency virus; Virus; Biology; Human immunodeficiency virus (HIV); HIV vaccine; Viral envelope; AIDS Vaccines; Antibody-dependent enhancement; Chemistry; Vaccine trial; Immunology; Viral replication; Epitope; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001586064,0.0002570408,0.0003580748,0.0002422444,0.0001297087,0.0002177382,0.0002153307,0.0003149147,0.001555257],"category_scores_gemma":[0.0001748428,0.00009996196,0.0001180422,0.00009319622,0.0001515428,0.000198678,0.0001679238,0.0005775765,0.0002481939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002258929,"about_ca_system_score_gemma":0.0002330003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002764282,"about_ca_topic_score_gemma":0.0004773439,"domain_scores_codex":[0.9998847,0.00002536835,0.000005971457,0.00001517411,0.00002392506,0.00004485047],"domain_scores_gemma":[0.9999052,0.00001964263,0.00001562896,0.000007284235,0.000009901458,0.00004230954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001621031,0.002368828,0.0006867237,0.0001008008,0.00002095629,0.00007945834,0.00002756539,0.0003921054,0.9738172,0.0002445546,0.0004192377,0.0202216],"study_design_scores_gemma":[0.000470457,0.02719119,0.006839741,0.00001797122,0.00005861895,0.000382221,0.00003023143,0.002419058,0.9571643,0.0001054661,0.005312061,0.000008593618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979699,0.0003980288,0.0002812527,0.00005904058,0.00003280539,0.00003476471,0.00004229669,0.00004596459,0.001135779],"genre_scores_gemma":[0.9976083,0.0002059339,0.0006883338,0.00004737999,0.00002480038,0.00002600771,0.000111376,0.00000568114,0.001281968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001555257,"threshold_uncertainty_score":0.005202889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02841559548057809,"score_gpt":0.3297879633616779,"score_spread":0.3013723678810998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}