{"id":"W2808596977","doi":"10.1111/tan.13307","title":"Inaccuracies in epitope repertoire estimations when using multilocus allele‐level HLA genotype imputation tools","year":2018,"lang":"en","type":"article","venue":"HLA","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; McGill University; Héma-Québec; McGill University Health Centre","funders":"","keywords":"Epitope; Imputation (statistics); Allele; Genotype; Human leukocyte antigen; Biology; Genetics; Immunology; Antigen; Gene; Statistics; Mathematics; Missing data","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002123172,0.0002056158,0.0002855052,0.0001877414,0.0003458456,0.00003600594,0.0002398889,0.0003592898,0.0007520124],"category_scores_gemma":[0.0002906321,0.0001898213,0.00006547837,0.0001781945,0.0003956928,0.000263126,0.0001356135,0.0002926669,0.001191044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009213016,"about_ca_system_score_gemma":0.0001083497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001125105,"about_ca_topic_score_gemma":0.0005183124,"domain_scores_codex":[0.9985539,0.0001959438,0.0004231305,0.0003576669,0.00003562011,0.0004337119],"domain_scores_gemma":[0.9991515,0.00017751,0.0001564319,0.0003427788,0.0001529525,0.00001887433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009945756,0.0001255528,0.00124585,0.00001260314,0.00005073979,0.00001031222,0.002289819,0.00005051453,0.9437123,0.0004249069,0.001188065,0.05078988],"study_design_scores_gemma":[0.005933406,0.0008299047,0.01920248,0.0001787117,0.0001499132,0.0005775358,0.001769978,0.002901985,0.7817626,0.005693638,0.1797231,0.001276735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908902,0.002042574,0.003994653,0.0004717635,0.0008500132,0.0002963586,0.00003462721,0.0001080721,0.001311714],"genre_scores_gemma":[0.9927404,0.00008446851,0.003982617,0.0001997573,0.0000775321,0.00002080501,0.0001813554,0.00002316799,0.00268993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.178535,"threshold_uncertainty_score":0.9995866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05833163007210659,"score_gpt":0.2895575577566706,"score_spread":0.231225927684564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}