{"id":"W2808608845","doi":"10.1158/1078-0432.ccr-17-3384","title":"Dual MAPK Inhibition Is an Effective Therapeutic Strategy for a Subset of Class II BRAF Mutant Melanomas","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Nickel Institute; Montreal General Hospital; McGill University; McGill University Health Centre","funders":"Melanoma Research Alliance; Canadian Institutes of Health Research; V Foundation for Cancer Research; U.S. Department of Defense","keywords":"Mutant; Melanoma; Cancer research; Class (philosophy); MAPK/ERK pathway; Medicine; Biology; Genetics; Computer science; Gene; Kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001864403,0.0001341086,0.0002567635,0.0000592762,0.000192606,0.00002097168,0.0001905933,0.0003247826,0.0001260963],"category_scores_gemma":[0.0002072134,0.000113166,0.0001507345,0.0001492517,0.0006324961,0.00000759155,0.0001544432,0.0002542142,0.00001273775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002729692,"about_ca_system_score_gemma":0.0003451967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001196297,"about_ca_topic_score_gemma":0.0004816292,"domain_scores_codex":[0.9978791,0.0004433877,0.0004015446,0.0005602742,0.0002872653,0.0004284351],"domain_scores_gemma":[0.9986128,0.0001455074,0.00009679329,0.0004494543,0.0005234463,0.0001719874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002121744,0.0004234387,0.002310408,0.00007446863,0.0001431377,0.000005553525,0.0001927692,0.000001264941,0.9452845,0.0008569443,0.00420611,0.0443797],"study_design_scores_gemma":[0.002086967,0.01845112,0.0126457,0.00003903359,0.00002636895,0.000005688834,0.000143717,0.000176917,0.9316084,0.002093737,0.03253085,0.0001915057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968555,0.0004475616,0.0002728225,0.0002714788,0.0002236869,0.0008160165,0.0002628429,0.000008744427,0.0008413271],"genre_scores_gemma":[0.9971939,0.000180018,0.00006592979,0.0002808772,0.0014382,0.0002726847,0.0001267112,0.00002771771,0.0004139264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04418819,"threshold_uncertainty_score":0.4614777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2133842519061688,"score_gpt":0.4963730221359454,"score_spread":0.2829887702297766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}