{"id":"W2808725650","doi":"10.1371/journal.pone.0198418","title":"(C2G4)n repeat expansion sequences from the C9orf72 gene form an unusual DNA higher-order structure in the pH range of 5-6","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Circular dichroism; DNA; Oligonucleotide; Gene; Trinucleotide repeat expansion; Base pair; Chemistry; Crystallography; Biology; Biophysics; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008341423,0.0002641066,0.0002207732,0.0002649465,0.0002400091,0.0002027121,0.0001649312,0.000457078,0.00181775],"category_scores_gemma":[0.0002373226,0.0001293172,0.0002061202,0.0001701363,0.0002493276,0.000133404,0.0002042534,0.0002991953,0.0005043573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001947598,"about_ca_system_score_gemma":0.0001408183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000390232,"about_ca_topic_score_gemma":0.0009975729,"domain_scores_codex":[0.999882,0.00001679485,0.000007779481,0.00004488651,0.00002910563,0.00001954704],"domain_scores_gemma":[0.999827,0.00002400069,0.00008232355,0.00001590305,0.00001571319,0.00003508624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001349405,0.00001738935,0.002126527,0.0000296404,0.00000993925,0.0005651278,0.00002765232,0.00009004478,0.9942026,0.0001088135,0.00008197489,0.002605289],"study_design_scores_gemma":[0.0000491766,0.0006571937,0.07901737,0.00001913925,0.000044311,0.009081446,0.0001224728,0.001685858,0.9030949,0.0006332408,0.005556342,0.00003851936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962107,0.0002872781,0.002177608,0.00007829747,0.00001917048,0.00001865098,0.00021638,0.00007911525,0.0009127847],"genre_scores_gemma":[0.9958732,0.00006420483,0.002785754,0.00007150588,0.000009928739,0.00001549068,0.0004054972,0.00001251326,0.0007618856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00181775,"threshold_uncertainty_score":0.006081045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0235865329175022,"score_gpt":0.2346451818119115,"score_spread":0.2110586488944093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}