{"id":"W2808730110","doi":"10.1038/s41467-018-04804-6","title":"Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":216,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; King Saud University","keywords":"Glycolysis; Cell biology; Motility; Bioenergetics; Biology; Oxidative phosphorylation; Dendritic cell; Context (archaeology); PI3K/AKT/mTOR pathway; Anaerobic glycolysis; Mitochondrion; Immune system; Chemistry; Metabolism; Signal transduction; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001099087,0.0001895502,0.0001736138,0.0001171885,0.000185533,0.0004354639,0.0001454239,0.0002280694,0.0009800942],"category_scores_gemma":[0.0001172531,0.0001065786,0.0002017888,0.0001040892,0.0001829733,0.0002666545,0.0001930375,0.0003914137,0.0003321952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003637343,"about_ca_system_score_gemma":0.0003187395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008773115,"about_ca_topic_score_gemma":0.001061309,"domain_scores_codex":[0.9998268,0.0000276014,0.00001401652,0.00003311094,0.00003283241,0.00006567781],"domain_scores_gemma":[0.9998659,0.0000130161,0.00003886493,0.00001837571,0.00001649889,0.00004734328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001272656,0.00001273402,0.0001973903,0.00001924433,0.000001182936,0.00002265971,0.000006518345,0.00002633802,0.9988423,0.0001552449,0.00002205624,0.00056702],"study_design_scores_gemma":[0.00001257966,0.0001051209,0.007471048,0.000006641222,0.000006681218,0.0001475522,0.00003008262,0.0005118346,0.9892389,0.00006233388,0.00240329,0.00000389231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940514,0.00172103,0.002142973,0.0001499967,0.00002570882,0.00001815994,0.00038945,0.00006531431,0.001435873],"genre_scores_gemma":[0.9970472,0.0005098001,0.001061161,0.000025769,0.000005332379,0.00001871212,0.0003541824,0.00001615866,0.0009616915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009800942,"threshold_uncertainty_score":0.003278792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028917103718141,"score_gpt":0.2795153632349173,"score_spread":0.2692261921977359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}