{"id":"W2808759948","doi":"10.1016/j.bbmt.2018.06.010","title":"Outcomes of Measurable Residual Disease in Pediatric Acute Myeloid Leukemia before and after Hematopoietic Stem Cell Transplant: Validation of Difference from Normal Flow Cytometry with Chimerism Studies and Wilms Tumor 1 Gene Expression","year":2018,"lang":"en","type":"article","venue":"Biology of Blood and Marrow Transplantation","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital; BC Children's Hospital; University of Calgary; Université de Montréal; Alberta Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Medicine; Minimal residual disease; Hematopoietic stem cell transplantation; Flow cytometry; Wilms' tumor; Myeloid leukemia; Internal medicine; Transplantation; Oncology; Prospective cohort study; Disease; Myeloid; Leukemia; Pathology; Gastroenterology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009389498,0.0002876444,0.0003941773,0.0004000154,0.0001972324,0.0004245039,0.0003190582,0.0003047208,0.0002627554],"category_scores_gemma":[0.002580309,0.0001914755,0.000306267,0.0003453749,0.0005550787,0.0003518144,0.0004417782,0.0003453441,0.00007731129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005445178,"about_ca_system_score_gemma":0.0004102607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001412264,"about_ca_topic_score_gemma":0.001670545,"domain_scores_codex":[0.999348,0.0002073843,0.00006349746,0.0001321415,0.0001483459,0.0001006813],"domain_scores_gemma":[0.9979043,0.0005354082,0.0009191419,0.0001350305,0.0001101768,0.000395923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006846472,0.00006444351,0.9947283,0.000007893279,0.00002153003,0.0002188142,0.0001235095,0.0001944673,0.001811235,0.00001892043,0.00002991022,0.002096364],"study_design_scores_gemma":[0.00004404614,0.001718568,0.9948651,0.000004275232,0.00003086245,0.001062939,0.0001049956,0.0006475976,0.001341786,0.000019842,0.0001531965,0.000006909216],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9998702,0.00004953833,0.00002388591,0.000003877201,5.965356e-7,0.000002443919,0.00002156877,0.000001085227,0.00002685865],"genre_scores_gemma":[0.9998094,0.00001839114,0.00003913189,0.000005794003,0.000002298205,0.000004681918,0.0001037,9.191132e-7,0.00001571236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001412264,"threshold_uncertainty_score":0.004965723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085202456923917,"score_gpt":0.2491018780430745,"score_spread":0.2382498534738353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}