{"id":"W2808765268","doi":"10.1038/s41588-018-0334-2","title":"Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution","year":2019,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University; Université de Montréal; Montreal Heart Institute","funders":"FP7 Ideas: European Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Helmholtz Zentrum München; National Human Genome Research Institute; Hrvatska Zaklada za Znanost; National Institute on Drug Abuse; Imperial College Healthcare NHS Trust; NIHR Oxford Biomedical Research Centre; Hjärt-Lungfonden; Medical Research Council; Scottish Funding Council; NIHR Cambridge Biomedical Research Centre; NIHR BioResource; Universiteit Leiden; National Heart, Lung, and Blood Institute; Kaiser Foundation Research Institute; Directorate for Biological Sciences; National Institutes of Health; H. Lundbeck A/S; Fondation Leenaards; Institut de Cardiologie de Montréal; Marcus och Amalia Wallenbergs minnesfond; Government of Western Australia; Paavo Nurmen Säätiö; Tampereen Tuberkuloosisäätiö; National Health and Medical Research Council; Deutsche Krebshilfe; Sydäntutkimussäätiö; Vetenskapsrådet; Novo Nordisk; National Institute for Health Research Health Protection Research Unit; Universitätsklinikum Regensburg; Diabetesliitto; Leids Universitair Medisch Centrum; Steno Diabetes Center Copenhagen; SystemsX.ch; Universitetet i Bergen; Emil Aaltosen Säätiö; Wake Forest School of Medicine; Taichung Veterans General Hospital; Helse Vest; National Cancer Institute; European Regional Development Fund; Max-Planck-Gesellschaft; Region Hovedstaden; Kuopion Yliopistollinen Sairaala; American Heart Association; Suomen Kulttuurirahasto; Turun Yliopistollinen Keskussairaala; European Commission; Knut och Alice Wallenbergs Stiftelse; Tekes; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Medical Research Council; Norges Forskningsråd; Australian Government; QIMR Berghofer Medical Research Institute; Lunds Universitet; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Eesti Teadusagentuur; Päivikki ja Sakari Sohlbergin Säätiö; Raine Medical Research Foundation; Public Health England; Edith Cowan University; Diabetestutkimussäätiö; Foundation for Cardiovascular Research; ZonMw; Université de Montréal; Kela; National Natural Science Foundation of China; National Science Council; British Heart Foundation; National Institute for Health and Care Research; Johns Hopkins University; Wellcome Trust; Cancer Research UK; Royal Marsden NHS Foundation Trust; Socialdepartementet; School of Medicine, Boston University; European Hematology Association; Li Ka Shing Foundation; University of Notre Dame; Imperial College London; Fondation Institut de Cardiologie de Montréal; NIHR Exeter Clinical Research Facility; Erasmus Medisch Centrum; Lundbeckfonden; Doktor Robert Pfleger-Stiftung; National Science Foundation; Fondation Leducq; Diabetesforbundet; Pfizer; Northwestern University; Horizon 2020 Framework Programme; University of Minnesota; Juho Vainion Säätiö; Novo Nordisk Fonden","keywords":"Biology; Genome-wide association study; Genetics; Gene; Body fat distribution; Minor allele frequency; Adipose tissue; Allele; Allele frequency; Endocrinology; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0009603184,0.0007782329,0.001652536,0.0001633728,0.0002790846,0.00007613959,0.0008091487,0.003026418,0.00001481306],"category_scores_gemma":[0.001333757,0.0007209605,0.0005750303,0.0006875013,0.00003748303,0.000003128256,0.0009080851,0.0009011401,0.0002034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002291867,"about_ca_system_score_gemma":0.0003376801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008500698,"about_ca_topic_score_gemma":0.000009783506,"domain_scores_codex":[0.9955974,0.0002601507,0.001171515,0.001408369,0.0002874946,0.00127513],"domain_scores_gemma":[0.9972012,0.00009060049,0.0006853209,0.001198597,0.0004549411,0.0003693383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004706283,0.000155596,0.0004739129,0.002329561,0.0011002,0.000005429542,0.0000302748,0.0002210098,0.01548829,0.000239255,0.01413516,0.9657742],"study_design_scores_gemma":[0.0003569052,0.0003033029,0.0007512337,0.000963873,0.000506828,0.00004083131,0.000009929861,0.00002445017,0.00107657,0.00002353051,0.9950979,0.0008446404],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00443711,0.9782982,0.009378358,0.0003940013,0.001173515,0.003314909,0.002827246,0.00004491869,0.0001317433],"genre_scores_gemma":[0.01026968,0.9757131,0.004810226,0.0004822308,0.001029218,0.0003535937,0.006401045,0.0001582733,0.0007825888],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9809628,"threshold_uncertainty_score":0.9995242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02312488381428673,"score_gpt":0.327225867781663,"score_spread":0.3041009839673763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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