{"id":"W2808765268","doi":"10.1038/s41588-018-0334-2","title":"Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution","year":2019,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University; Université de Montréal; Montreal Heart Institute","funders":"FP7 Ideas: European Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Helmholtz Zentrum München; National Human Genome Research Institute; Hrvatska Zaklada za Znanost; National Institute on Drug Abuse; Imperial College Healthcare NHS Trust; NIHR Oxford Biomedical Research Centre; Hjärt-Lungfonden; Medical Research Council; Scottish Funding Council; NIHR Cambridge Biomedical Research Centre; NIHR BioResource; Universiteit Leiden; National Heart, Lung, and Blood Institute; Kaiser Foundation Research Institute; Directorate for Biological Sciences; National Institutes of Health; H. Lundbeck A/S; Fondation Leenaards; Institut de Cardiologie de Montréal; Marcus och Amalia Wallenbergs minnesfond; Government of Western Australia; Paavo Nurmen Säätiö; Tampereen Tuberkuloosisäätiö; National Health and Medical Research Council; Deutsche Krebshilfe; Sydäntutkimussäätiö; Vetenskapsrådet; Novo Nordisk; National Institute for Health Research Health Protection Research Unit; Universitätsklinikum Regensburg; Diabetesliitto; Leids Universitair Medisch Centrum; Steno Diabetes Center Copenhagen; SystemsX.ch; Universitetet i Bergen; Emil Aaltosen Säätiö; Wake Forest School of Medicine; Taichung Veterans General Hospital; Helse Vest; National Cancer Institute; European Regional Development Fund; Max-Planck-Gesellschaft; Region Hovedstaden; Kuopion Yliopistollinen Sairaala; American Heart Association; Suomen Kulttuurirahasto; Turun Yliopistollinen Keskussairaala; European Commission; Knut och Alice Wallenbergs Stiftelse; Tekes; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Medical Research Council; Norges Forskningsråd; Australian Government; QIMR Berghofer Medical Research Institute; Lunds Universitet; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Eesti Teadusagentuur; Päivikki ja Sakari Sohlbergin Säätiö; Raine Medical Research Foundation; Public Health England; Edith Cowan University; Diabetestutkimussäätiö; Foundation for Cardiovascular Research; ZonMw; Université de Montréal; Kela; National Natural Science Foundation of China; National Science Council; British Heart Foundation; National Institute for Health and Care Research; Johns Hopkins University; Wellcome Trust; Cancer Research UK; Royal Marsden NHS Foundation Trust; Socialdepartementet; School of Medicine, Boston University; European Hematology Association; Li Ka Shing Foundation; University of Notre Dame; Imperial College London; Fondation Institut de Cardiologie de Montréal; NIHR Exeter Clinical Research Facility; Erasmus Medisch Centrum; Lundbeckfonden; Doktor Robert Pfleger-Stiftung; National Science Foundation; Fondation Leducq; Diabetesforbundet; Pfizer; Northwestern University; Horizon 2020 Framework Programme; University of Minnesota; Juho Vainion Säätiö; Novo Nordisk Fonden","keywords":"Biology; Genome-wide association study; Genetics; Gene; Body fat distribution; Minor allele frequency; Adipose tissue; Allele; Allele frequency; Endocrinology; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001085566,0.001300808,0.001693424,0.001862345,0.0001800996,0.0009505909,0.001203831,0.001684498,0.002940163],"category_scores_gemma":[0.001783201,0.0002488922,0.0005099057,0.002364197,0.0006835825,0.0008152817,0.0007025556,0.00202896,0.001458039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000685378,"about_ca_system_score_gemma":0.001204628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001998897,"about_ca_topic_score_gemma":0.003256736,"domain_scores_codex":[0.9997157,0.00005464944,0.00004742694,0.000076951,0.00008304136,0.0000221525],"domain_scores_gemma":[0.998888,0.000720282,0.0001067087,0.00002781623,0.0001894114,0.00006785512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.000137885,0.00004579512,0.001175309,0.008860577,0.0003177693,0.0004323482,0.00002882734,0.0003017769,0.0009402635,0.004182522,0.06846228,0.9151146],"study_design_scores_gemma":[0.00006181046,0.00006391166,0.005086299,0.006119876,0.0006391919,0.002729817,0.00007495847,0.0001675322,0.0003653732,0.006049272,0.9785963,0.00004560653],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000950273,0.9972445,0.0003024417,0.001161951,0.0005123465,0.000002934932,0.0000587528,0.00001049959,0.0006116493],"genre_scores_gemma":[0.0006471261,0.9968023,0.0003867927,0.000706117,0.0008106947,0.000005932974,0.00008587532,0.00000248249,0.0005526495],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002940163,"threshold_uncertainty_score":0.00983578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02312488381428673,"score_gpt":0.327225867781663,"score_spread":0.3041009839673763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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