{"id":"W2808767859","doi":"10.1093/neuonc/noy059.175","title":"EAPH-06. HYPERMUTANT PEDIATRIC HIGH GRADE GLIOMAS ARE DRIVEN BY RAS/MAPK MUTATIONS AND RESPOND TO MEK INHIBITION","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Trametinib; Selumetinib; MAPK/ERK pathway; Medicine; Cancer research; MEK inhibitor; Mutation; Biology; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001326853,0.0002933485,0.0002490924,0.000207216,0.0001709539,0.0004055786,0.0001699447,0.0003017342,0.00281291],"category_scores_gemma":[0.0001932771,0.0001265499,0.0002703985,0.0002434238,0.00014193,0.0001230217,0.0001940962,0.0007323676,0.0008920654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003435293,"about_ca_system_score_gemma":0.0003543188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001520923,"about_ca_topic_score_gemma":0.00244437,"domain_scores_codex":[0.9998615,0.00001532898,0.00001016463,0.00002989617,0.00004190729,0.00004123111],"domain_scores_gemma":[0.9998564,0.00001951728,0.00002932278,0.00001719764,0.00001626206,0.0000614253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00210837,0.0004767226,0.01596927,0.0002263882,0.00008610833,0.001912926,0.0001068899,0.0008586794,0.9325061,0.0005465867,0.006138403,0.03906351],"study_design_scores_gemma":[0.0003506322,0.003911722,0.203575,0.00005972211,0.000131769,0.02508476,0.0003196796,0.004104229,0.7021506,0.0005728553,0.0597001,0.00003885209],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854532,0.000979558,0.0009914497,0.0002131945,0.00003586626,0.00006556986,0.007160734,0.0002572323,0.004843241],"genre_scores_gemma":[0.9766601,0.0008006812,0.002498206,0.0003258493,0.000009632818,0.0001038765,0.01533358,0.00009458207,0.00417343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00281291,"threshold_uncertainty_score":0.009410143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01827741763187357,"score_gpt":0.2920584435976439,"score_spread":0.2737810259657704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}