{"id":"W2808773455","doi":"10.3389/fimmu.2018.01400","title":"Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North","funders":"Universitair Medisch Centrum Groningen; Rijksuniversiteit Groningen; Center for Information Technology; Jan Kornelis de Cock Stichting","keywords":"CD28; microRNA; clone (Java method); Biology; Population; Ex vivo; T cell; Immunology; In vivo; Genetics; Medicine; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002543285,0.0001832516,0.000262831,0.0002276898,0.0001241159,0.0002720254,0.00009625586,0.0001852733,0.0006909733],"category_scores_gemma":[0.0004473592,0.0001412845,0.0002109418,0.0002185848,0.0001241772,0.0001168342,0.0001559926,0.0002533114,0.000339383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000151784,"about_ca_system_score_gemma":0.0001430553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000347959,"about_ca_topic_score_gemma":0.0002703479,"domain_scores_codex":[0.9997854,0.00004280543,0.00001922933,0.00006619366,0.0000559555,0.00003058369],"domain_scores_gemma":[0.9998509,0.00003187457,0.00004952755,0.00001858502,0.00003008398,0.0000190563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006382036,0.00003434868,0.006215095,0.00005911026,0.00002205186,0.0001508327,0.0001031542,0.0001390116,0.9853324,0.00007990551,0.0000970902,0.007128754],"study_design_scores_gemma":[0.00004757196,0.0009965488,0.1779331,0.00001379589,0.00009469569,0.001334787,0.0001204593,0.002900424,0.8103045,0.0002549632,0.005981591,0.00001774166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927207,0.002795273,0.003356572,0.00003943663,0.00002070633,0.0000261308,0.0003054367,0.0000519736,0.0006838248],"genre_scores_gemma":[0.9966843,0.0006149628,0.001751786,0.00003988617,0.00001008712,0.00003920059,0.0002759344,0.000009695464,0.0005742625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006909733,"threshold_uncertainty_score":0.002311528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005944777403362041,"score_gpt":0.2355635484603112,"score_spread":0.2296187710569492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}