{"id":"W2808774077","doi":"10.1093/neuonc/noy059.497","title":"MBRS-52. TARGETING PRUNE-1 IN A GEMM OF METASTATIC MEDULLOBLASTOMA: A POTENTIAL ROUTE OF INHIBITION FOR NEW FUTURE THERAPIES","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Mechanisms of cancer metastasis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medulloblastoma; Cancer research; In vivo; Biology; Metastasis; PTEN; Cancer; Signal transduction; Cell biology; PI3K/AKT/mTOR pathway; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130901,0.0002950162,0.0002966074,0.0002534418,0.00009662232,0.0002392761,0.0002495233,0.0003017537,0.001234514],"category_scores_gemma":[0.00007991932,0.0001319493,0.0002886984,0.0001344517,0.0001862331,0.0001893201,0.0001202669,0.0007596113,0.0003855151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003579278,"about_ca_system_score_gemma":0.0001915306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001264586,"about_ca_topic_score_gemma":0.002899761,"domain_scores_codex":[0.9999329,0.000009877795,0.000004440932,0.00001529491,0.00002138584,0.00001621497],"domain_scores_gemma":[0.999969,0.000003869941,0.000009867606,0.000003715211,0.000004253985,0.00000919413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003182938,0.0000974654,0.0001888053,0.0001710396,0.00002342398,0.0001428477,0.00003072916,0.0004045377,0.9859099,0.0005874212,0.0006230595,0.01150244],"study_design_scores_gemma":[0.0002066745,0.001686217,0.003463761,0.00003485737,0.00008426893,0.001002597,0.00003251367,0.002017651,0.9575268,0.0002265366,0.03370374,0.00001433805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9496283,0.02505819,0.01313156,0.0008895168,0.0001686938,0.0003112885,0.001488075,0.0008254167,0.008498979],"genre_scores_gemma":[0.9765279,0.007638289,0.006747381,0.0001648275,0.00002069387,0.0001180829,0.001722756,0.0000547015,0.007005224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001264586,"threshold_uncertainty_score":0.004129827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01376048979552226,"score_gpt":0.2890519646922945,"score_spread":0.2752914748967722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}