{"id":"W2808774077","doi":"10.1093/neuonc/noy059.497","title":"MBRS-52. TARGETING PRUNE-1 IN A GEMM OF METASTATIC MEDULLOBLASTOMA: A POTENTIAL ROUTE OF INHIBITION FOR NEW FUTURE THERAPIES","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Mechanisms of cancer metastasis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medulloblastoma; Cancer research; In vivo; Biology; Metastasis; PTEN; Cancer; Signal transduction; Cell biology; PI3K/AKT/mTOR pathway; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003728864,0.0001757143,0.0004152129,0.0001192483,0.00003542147,0.00000573996,0.0001799178,0.000177569,0.00005013999],"category_scores_gemma":[0.0002393184,0.0001681537,0.0001493405,0.000151366,0.0001453359,0.000009105339,0.0001005644,0.0001018922,0.000001798234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002893099,"about_ca_system_score_gemma":0.0003666109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004234268,"about_ca_topic_score_gemma":0.0002141005,"domain_scores_codex":[0.9984885,0.0002013041,0.0004984607,0.0003689608,0.0001517526,0.0002910568],"domain_scores_gemma":[0.9990183,0.00005459006,0.0003921364,0.0002506966,0.0002116187,0.00007262384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008827111,0.0001173543,0.00004090958,0.00006229146,0.00007603235,0.00000647644,0.0003111376,0.00002464042,0.9802319,0.0003428741,0.002712021,0.0151917],"study_design_scores_gemma":[0.002378381,0.003441659,0.0000905329,0.00001531463,0.00007458832,0.00002664815,0.0003875012,0.00008796449,0.9196673,0.0009130693,0.0727858,0.0001312381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782413,0.0009940038,0.01799406,0.001183126,0.0007003407,0.0006304784,0.00007964564,0.00001117653,0.0001658416],"genre_scores_gemma":[0.9704693,0.000169705,0.02791253,0.0005019808,0.0007643381,0.00006043749,0.00006214937,0.00003399726,0.00002557237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07007378,"threshold_uncertainty_score":0.6857107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01376048979552226,"score_gpt":0.2890519646922945,"score_spread":0.2752914748967722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}