{"id":"W2808789194","doi":"10.2337/db18-503-p","title":"PBI-4050 Improves Metabolic Regulation and Diabetic Nephropathy through Reduction of ER Stress, Pro-Inflammatory/Fibrotic Markers, Galectin-3 Expression, and Inflammatory Cell Infiltration in ob/ob Mouse Model","year":2018,"lang":"en","type":"article","venue":"Diabetes","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Medicine; CTGF; Internal medicine; Endocrinology; Adiponectin; Kidney; Diabetic nephropathy; Fibrosis; Adipose tissue; Diabetes mellitus; Insulin resistance; Growth factor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783626,0.0005633048,0.0006581362,0.0006068193,0.0001907182,0.0002735226,0.000307585,0.0004510552,0.001784055],"category_scores_gemma":[0.00006767751,0.0002585768,0.000484679,0.000289119,0.0002952796,0.0002986191,0.0001422062,0.001157708,0.0002816697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002470931,"about_ca_system_score_gemma":0.0004342915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006572859,"about_ca_topic_score_gemma":0.00109051,"domain_scores_codex":[0.9999032,0.000008939822,0.00001127618,0.00001871716,0.00002667299,0.00003112236],"domain_scores_gemma":[0.9998965,0.000005146816,0.00003852136,0.000007929343,0.00001054476,0.00004139716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005098416,0.001754564,0.0005705734,0.0003737955,0.00006305311,0.00009379408,0.00003148781,0.0002139044,0.982502,0.0001204358,0.0002418486,0.008936265],"study_design_scores_gemma":[0.002028904,0.02211716,0.02549533,0.00009823734,0.0003338062,0.0006741623,0.0001168078,0.001549584,0.9419901,0.0002409257,0.005320533,0.00003442212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940865,0.003112903,0.0009188225,0.0001953407,0.00005434006,0.0000479441,0.0004129888,0.0001808786,0.0009901526],"genre_scores_gemma":[0.9889584,0.003570562,0.002865887,0.0002481602,0.00003446486,0.00009755684,0.0008344896,0.00004129178,0.003349221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001784055,"threshold_uncertainty_score":0.005968273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009274590348498764,"score_gpt":0.2380753668135295,"score_spread":0.2288007764650307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}