{"id":"W2808789194","doi":"10.2337/db18-503-p","title":"PBI-4050 Improves Metabolic Regulation and Diabetic Nephropathy through Reduction of ER Stress, Pro-Inflammatory/Fibrotic Markers, Galectin-3 Expression, and Inflammatory Cell Infiltration in ob/ob Mouse Model","year":2018,"lang":"en","type":"article","venue":"Diabetes","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Medicine; CTGF; Internal medicine; Endocrinology; Adiponectin; Kidney; Diabetic nephropathy; Fibrosis; Adipose tissue; Diabetes mellitus; Insulin resistance; Growth factor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002877062,0.0002259742,0.0002431358,0.0001339617,0.0001013371,0.00004547924,0.000110751,0.0001962067,0.0000117251],"category_scores_gemma":[0.0001842943,0.0002241966,0.0000403306,0.000142845,0.0003487618,0.00006825213,0.0001450092,0.0001314364,0.000001540407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002126403,"about_ca_system_score_gemma":0.00008667397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002412543,"about_ca_topic_score_gemma":0.00002155321,"domain_scores_codex":[0.9984787,0.0001812623,0.0003537684,0.0004440152,0.0002064863,0.0003357946],"domain_scores_gemma":[0.9991294,0.00003324579,0.0001824663,0.0003539527,0.0002195836,0.00008132729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001107831,0.00004024777,0.05318353,0.0002044746,0.00002198763,1.693395e-7,0.000471326,0.0000413714,0.9445273,0.00003501394,0.00008436065,0.001279476],"study_design_scores_gemma":[0.0006240176,0.0002177931,0.08232699,0.00006464765,0.00002021827,6.747081e-7,0.000191533,0.002286192,0.913451,0.0005183122,0.00008656269,0.0002121075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997285,0.001640381,0.000168631,0.00002612102,0.00005588377,0.0006649777,0.00002081602,0.00001947912,0.0001187222],"genre_scores_gemma":[0.9985577,0.0002233764,0.0007139405,0.000011192,0.00016739,0.00006861678,0.00006428577,0.00003784119,0.0001556384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03107631,"threshold_uncertainty_score":0.914247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009274590348498764,"score_gpt":0.2380753668135295,"score_spread":0.2288007764650307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}