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Komen; Korea Health Industry Development Institute; Suomen Kulttuurirahasto; Fred C. and Katherine B. Andersen Foundation; ZonMw; Astellas Pharma; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Taiwan Biobank; Vlaamse regering; National Research Foundation; Cancer Care Ontario; Universität Basel; Novo Nordisk; University of Pennsylvania; Heart and Stroke Foundation of Canada; European Foundation for the Study of Diabetes; China Medical University Hospital; Irish Cancer Society; Sanofi; American Academy of Dermatology; Vanderbilt University; Shanghai Municipal Education Commission; Federal Emergency Management Agency; GlaxoSmithKline; Associazione Italiana per la Ricerca sul Cancro; Congressionally Directed Medical Research Programs; Chinese University of Hong Kong; U.S. Department of Defense; Eli Lilly and Company; Canadian Institutes of Health Research; Diabetes UK; Mayo Foundation for Medical Education and Research; European Commission; Kidney Foundation of Canada; Breast Cancer Research Foundation; U.S. Department of Homeland Security; National Research Program for Biopharmaceuticals; Pfizer","keywords":"Metformin; Medicine; Type 2 diabetes; Internal medicine; Oncology; Systematic review; Cancer; Diabetes mellitus; Prostate cancer; Meta-analysis; MEDLINE; Cochrane Library; Breast cancer; Endocrinology; Insulin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008248119,0.001240693,0.007827831,0.009338855,0.0004723224,0.002328567,0.00123319,0.001547554,0.00407652],"category_scores_gemma":[0.0422026,0.0008718366,0.008362763,0.009712938,0.0006931604,0.001699892,0.001321356,0.001035516,0.0002645474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002868278,"about_ca_system_score_gemma":0.00958467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009096708,"about_ca_topic_score_gemma":0.01845106,"domain_scores_codex":[0.9928933,0.002919238,0.002422929,0.0005207197,0.001032587,0.0002112561],"domain_scores_gemma":[0.9724181,0.02058441,0.004455732,0.0003434355,0.001934812,0.0002634389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0003129231,0.00001900111,0.001678935,0.9355458,0.03094847,0.00007732143,0.0001479823,0.0001467881,0.0001018,0.0002048551,0.001055354,0.02976073],"study_design_scores_gemma":[0.0005094816,0.0002538319,0.005872717,0.7733041,0.2098315,0.0002765697,0.0002141009,0.0001347397,0.0001523491,0.0004224853,0.008990404,0.00003764134],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001531473,0.9970484,0.0001440893,0.0003165429,0.0001074743,0.0002626599,0.0003390727,0.000007889742,0.0002422688],"genre_scores_gemma":[0.03081371,0.9671309,0.0006491371,0.0004848648,0.0001123582,0.0004789706,0.0002399092,0.000005765852,0.00008435214],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009338855,"threshold_uncertainty_score":0.04362077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007014010942342766,"score_gpt":0.2404069502993746,"score_spread":0.2333929393570319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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