{"id":"W2808796425","doi":"10.1158/0008-5472.can-18-0027","title":"CD271+ Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Hospital for Sick Children; University of Toronto; Calgary Laboratory Services; University of Manitoba; Ottawa Hospital; Children's Hospital Research Institute of Manitoba","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Government of Canada","keywords":"Medulloblastoma; Vismodegib; Selumetinib; Sonic hedgehog; Cancer research; Smoothened; Progenitor cell; Biology; MEK inhibitor; Population; MAPK/ERK pathway; Medicine; Stem cell; Hedgehog signaling pathway; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004089434,0.0001230421,0.0001402372,0.00009543172,0.0001116088,0.00004111127,0.0001240868,0.0001424938,0.00004844135],"category_scores_gemma":[0.0004602745,0.0001138155,0.00001654375,0.0001849916,0.0003626586,0.000006069312,0.0002423117,0.0002016222,0.00001610465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002916203,"about_ca_system_score_gemma":0.0001333609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002278971,"about_ca_topic_score_gemma":0.001334853,"domain_scores_codex":[0.9986373,0.0001607641,0.0001077684,0.0004613616,0.0001942985,0.0004384718],"domain_scores_gemma":[0.999287,0.0001319155,0.00003233293,0.0002366064,0.0001537834,0.0001583316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001418195,0.00004743391,0.043128,0.00007810266,0.0000131492,0.00002752579,0.00009846081,5.50627e-7,0.9509234,0.00001887621,0.001561504,0.003961134],"study_design_scores_gemma":[0.0005623894,0.0005591955,0.1123174,0.0001010485,0.000005204667,0.000008468266,0.00008476053,0.00003683486,0.8798975,0.00008017846,0.006198305,0.0001487472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976147,0.00129476,0.0000215664,0.0002089865,0.00009112352,0.000400115,0.00003324046,0.000008404017,0.0003270789],"genre_scores_gemma":[0.9981307,0.0008771479,0.00003187332,0.00005086992,0.0002753568,0.0001553584,0.000008032287,0.00002009642,0.0004505373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07102598,"threshold_uncertainty_score":0.464126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03472977013912622,"score_gpt":0.3341570793208322,"score_spread":0.299427309181706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}