{"id":"W2808866479","doi":"10.1093/neuonc/noy059.148","title":"DIPG-55. TARGETING SENESCENT CELLS WITH ABT-263 ENHANCES CELL DEATH INDUCED BY BMI1 INHIBITION AND IONIZING RADIATION IN DIPG","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"BMI1; Cancer research; Senescence; Apoptosis; Cell culture; Cell growth; Radioresistance; In vivo; Growth inhibition; Programmed cell death; Biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067343,0.0004006403,0.000333507,0.0002867627,0.0001301419,0.000212766,0.0001892123,0.0002457579,0.001362809],"category_scores_gemma":[0.00005439872,0.0001247126,0.0003459974,0.0002060231,0.0002302359,0.000149531,0.0001741487,0.0008093012,0.0003853808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002546296,"about_ca_system_score_gemma":0.0002035562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065972,"about_ca_topic_score_gemma":0.001659577,"domain_scores_codex":[0.999925,0.000008652782,0.000007379142,0.00001548131,0.00001937298,0.00002407444],"domain_scores_gemma":[0.999936,0.000006039149,0.0000128882,0.000006799264,0.000004848522,0.00003340959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000276008,0.0001146127,0.0001548677,0.00006743817,0.000008240659,0.00008216078,0.00001403097,0.00009950114,0.9972023,0.00007914168,0.0001108092,0.001790883],"study_design_scores_gemma":[0.00008100065,0.002341585,0.006530322,0.00001191921,0.00003224648,0.0003487197,0.00002956148,0.0006845396,0.9865931,0.00003985257,0.003301212,0.000005925957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932246,0.00239368,0.001505089,0.0001424067,0.00007813666,0.00007552825,0.0007370153,0.0001701351,0.001673429],"genre_scores_gemma":[0.992453,0.001502087,0.001619568,0.00009880049,0.0000124238,0.00006446421,0.0012991,0.0000252113,0.002925379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001362809,"threshold_uncertainty_score":0.00455904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562984796073893,"score_gpt":0.2691519641668976,"score_spread":0.2535221162061587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}