{"id":"W2808886822","doi":"10.1093/jnci/djy099","title":"Novel Common Genetic Susceptibility Loci for Colorectal Cancer","year":2018,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":190,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Institute of Aging; Memorial University of Newfoundland; Ontario Institute for Cancer Research; Mount Sinai Hospital; Cancer Care Ontario","funders":"Common Fund; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Cancer Institute; NIH Office of the Director; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Ontario Ministry of Research and Innovation; Instituto de Salud Carlos III; University of Miami; Japan Society for the Promotion of Science; National Human Genome Research Institute; California Department of Public Health; School of Medicine, Vanderbilt University; Cancer Council Victoria; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Chonnam National University Hwasun Hospital; Seventh Framework Programme; Wereld Kanker Onderzoek Fonds; Conseil Régional des Pays de la Loire; Stanford University; Vetenskapsrådet; Stockholms Läns Landsting; Ontario Ministry of Research, Innovation and Science; Servicio Gallego de Salud; Norris Cotton Cancer Center; Ministry of Education, Culture, Sports, Science and Technology; Ministerio de Economía y Competitividad; Chonnam National University; ZonMw; Canadian Cancer Society Research Institute; Deutsche Forschungsgemeinschaft; Ontario Institute for Cancer Research; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; Vanderbilt University; State of Connecticut Department of Public Health; University of Chicago; World Cancer Research Fund International; Memorial Sloan-Kettering Cancer Center; Junta de Castilla y León; World Health Organization; University of North Carolina; Division of Cancer Prevention, National Cancer Institute; Harvard University; American Cancer Society; Université de Genève; Federación Española de Enfermedades Raras; Wageningen University and Research; Cancer Research UK; Transcan; European Commission; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Roswell Park Cancer Institute; Fred Hutchinson Cancer Research Center; University of Pennsylvania; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Broad Institute; U.S. Department of Health and Human Services","keywords":"Colorectal cancer; Genetics; Genetic predisposition; Biology; Cancer; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004821351,0.0001001311,0.0001690543,0.00003221796,0.0001994396,0.00001166579,0.0003164499,0.0001219608,0.00003281541],"category_scores_gemma":[0.0004891584,0.00007177397,0.0001827094,0.00009573762,0.0002331096,0.000007278501,0.00006857471,0.0001034826,0.00000126987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001900309,"about_ca_system_score_gemma":0.0007178172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001408683,"about_ca_topic_score_gemma":0.003191196,"domain_scores_codex":[0.9990296,0.00004570927,0.000376542,0.0001478129,0.0002317326,0.0001686199],"domain_scores_gemma":[0.9982151,0.00003198106,0.0004343499,0.0000908005,0.001174569,0.00005315594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005537051,0.0001903159,0.2337434,0.00002730961,0.0005229161,3.277277e-7,0.0001279157,0.01570606,0.6326909,0.0003693358,0.1098379,0.006229951],"study_design_scores_gemma":[0.00171229,0.0004823671,0.7304633,0.00003056343,0.0001049547,0.00006076985,0.00002026095,0.000871908,0.04802118,0.001718856,0.216297,0.0002165032],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898938,0.0005158071,0.004428843,0.002177149,0.002333393,0.0001862122,0.0002095399,0.000002041583,0.0002532194],"genre_scores_gemma":[0.9910458,0.0001400377,0.003585508,0.001320232,0.003611127,0.00003196258,0.00001176708,0.000009534396,0.0002440226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5846697,"threshold_uncertainty_score":0.2926857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04606337993772799,"score_gpt":0.3584859405702442,"score_spread":0.3124225606325162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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