{"id":"W2808886822","doi":"10.1093/jnci/djy099","title":"Novel Common Genetic Susceptibility Loci for Colorectal Cancer","year":2018,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":190,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Institute of Aging; Memorial University of Newfoundland; Ontario Institute for Cancer Research; Mount Sinai Hospital; Cancer Care Ontario","funders":"Common Fund; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Cancer Institute; NIH Office of the Director; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Ontario Ministry of Research and Innovation; Instituto de Salud Carlos III; University of Miami; Japan Society for the Promotion of Science; National Human Genome Research Institute; California Department of Public Health; School of Medicine, Vanderbilt University; Cancer Council Victoria; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Chonnam National University Hwasun Hospital; Seventh Framework Programme; Wereld Kanker Onderzoek Fonds; Conseil Régional des Pays de la Loire; Stanford University; Vetenskapsrådet; Stockholms Läns Landsting; Ontario Ministry of Research, Innovation and Science; Servicio Gallego de Salud; Norris Cotton Cancer Center; Ministry of Education, Culture, Sports, Science and Technology; Ministerio de Economía y Competitividad; Chonnam National University; ZonMw; Canadian Cancer Society Research Institute; Deutsche Forschungsgemeinschaft; Ontario Institute for Cancer Research; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; Vanderbilt University; State of Connecticut Department of Public Health; University of Chicago; World Cancer Research Fund International; Memorial Sloan-Kettering Cancer Center; Junta de Castilla y León; World Health Organization; University of North Carolina; Division of Cancer Prevention, National Cancer Institute; Harvard University; American Cancer Society; Université de Genève; Federación Española de Enfermedades Raras; Wageningen University and Research; Cancer Research UK; Transcan; European Commission; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Roswell Park Cancer Institute; Fred Hutchinson Cancer Research Center; University of Pennsylvania; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Broad Institute; U.S. Department of Health and Human Services","keywords":"Colorectal cancer; Genetics; Genetic predisposition; Biology; Cancer; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001117277,0.0007720463,0.0006929719,0.001346191,0.0004302057,0.000731526,0.0006632674,0.0008117325,0.003348322],"category_scores_gemma":[0.002688255,0.0002994379,0.001072918,0.001889703,0.0005790491,0.0002826979,0.0006523072,0.0007424438,0.0003222358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004814129,"about_ca_system_score_gemma":0.0007805973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002120493,"about_ca_topic_score_gemma":0.003743544,"domain_scores_codex":[0.9991422,0.0001224725,0.00009157177,0.000341562,0.0002220294,0.00008017772],"domain_scores_gemma":[0.9979888,0.0005455449,0.0008647458,0.0002067198,0.0002138138,0.0001802846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003792668,0.0003156065,0.8198877,0.001388971,0.005542809,0.01424549,0.0005797247,0.003312121,0.07868776,0.003379109,0.002905326,0.06596275],"study_design_scores_gemma":[0.0006838808,0.0006880375,0.9525525,0.0001663099,0.004134568,0.01957385,0.0001895027,0.003462492,0.006085827,0.00382384,0.008573184,0.0000659674],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783154,0.008888441,0.007748896,0.0007975487,0.0001285617,0.0000948675,0.001756522,0.0001843277,0.002085489],"genre_scores_gemma":[0.9914508,0.001731993,0.00478168,0.0001577376,0.0001502994,0.00004311381,0.001093655,0.00001988404,0.0005707922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003348322,"threshold_uncertainty_score":0.01120126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04606337993772799,"score_gpt":0.3584859405702442,"score_spread":0.3124225606325162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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