{"id":"W2808914432","doi":"10.1021/acs.bioconjchem.8b00320","title":"Tuning the Diels–Alder Reaction for Bioconjugation to Maleimide Drug-Linkers","year":2018,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Materials Research; Natural Sciences and Engineering Research Council of Canada; Materials Research Science and Engineering Center, Harvard University; MedImmune; University of California, Santa Barbara; National Institutes of Health; National Science Foundation","keywords":"Maleimide; Chemistry; Conjugate; Bioconjugation; Thiol; Combinatorial chemistry; Adduct; Diels–Alder reaction; Organic chemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003374592,0.0001896494,0.0002007663,0.00004109083,0.0003165024,0.00004433854,0.0001749782,0.0001094679,0.000263776],"category_scores_gemma":[0.0001933401,0.0001309346,0.0001391506,0.0002002749,0.0002418268,0.0000594484,0.00008331898,0.0001988055,0.0002092083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008251315,"about_ca_system_score_gemma":0.0001028506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001117876,"about_ca_topic_score_gemma":0.000009898593,"domain_scores_codex":[0.99864,0.00001806724,0.0002676807,0.0003745142,0.0002875237,0.0004122104],"domain_scores_gemma":[0.9988845,0.0001280681,0.00007487695,0.0003566284,0.0003143504,0.0002415632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007273502,0.00004658843,0.001000589,0.0002196697,0.00007285201,0.000005323682,0.0002612735,4.840627e-7,0.9731861,0.0000999438,0.01851291,0.005866948],"study_design_scores_gemma":[0.0005889418,0.0001256323,0.002447587,0.0001149586,0.00004456011,0.00004572343,0.000310784,0.000253305,0.7042726,0.0001443199,0.291488,0.0001635525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679868,0.0001461617,0.0002218302,0.01773699,0.0002064758,0.0008629372,0.00004001412,0.00007874425,0.01272011],"genre_scores_gemma":[0.9653415,0.00005610748,0.001040769,0.00201205,0.0022547,0.0001980401,0.0001409964,0.00003760206,0.02891821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2729751,"threshold_uncertainty_score":0.5339357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03297377394987023,"score_gpt":0.3290009514707025,"score_spread":0.2960271775208323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}