{"id":"W2808914432","doi":"10.1021/acs.bioconjchem.8b00320","title":"Tuning the Diels–Alder Reaction for Bioconjugation to Maleimide Drug-Linkers","year":2018,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Materials Research; Natural Sciences and Engineering Research Council of Canada; Materials Research Science and Engineering Center, Harvard University; MedImmune; University of California, Santa Barbara; National Institutes of Health; National Science Foundation","keywords":"Maleimide; Chemistry; Conjugate; Bioconjugation; Thiol; Combinatorial chemistry; Adduct; Diels–Alder reaction; Organic chemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008095148,0.0005334846,0.0001679854,0.0002748032,0.0001167911,0.0002219156,0.0002468577,0.0002724004,0.0007894006],"category_scores_gemma":[0.000528187,0.0001787932,0.0001460626,0.0002657943,0.0002506046,0.0003182479,0.0002253618,0.0003361231,0.000321588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003013248,"about_ca_system_score_gemma":0.000153114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002130218,"about_ca_topic_score_gemma":0.0006431193,"domain_scores_codex":[0.9996605,0.00009326517,0.00003113238,0.00006440224,0.0001017103,0.00004905921],"domain_scores_gemma":[0.9998164,0.00006445991,0.00005363709,0.00001580906,0.00003423182,0.00001553832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003412297,0.00002321013,0.00008936114,0.00008355732,0.00000758567,0.00004194275,0.00004259997,0.0002643764,0.9955238,0.0003775345,0.00005351888,0.003458353],"study_design_scores_gemma":[0.000004406963,0.00009552594,0.0002315959,0.000002112221,0.00000465275,0.00004465156,0.000004418347,0.0005035361,0.9975839,0.00002290887,0.001498614,0.000003822204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9486426,0.003022353,0.04288721,0.0001282111,0.00004843334,0.0002465956,0.0001320905,0.0002043617,0.004688198],"genre_scores_gemma":[0.9656957,0.00287632,0.02838624,0.00007615611,0.00001671786,0.0001229479,0.0001336445,0.00005560409,0.002636556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008095148,"threshold_uncertainty_score":0.004281223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03297377394987023,"score_gpt":0.3290009514707025,"score_spread":0.2960271775208323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}