{"id":"W2808989994","doi":"10.1242/dmm.033563","title":"Octopamine signaling in the metazoan pathogen<i>S</i><i>chistosoma mansoni</i>: localization, small-molecule screening and opportunities for drug development","year":2018,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; University of California, San Francisco; National Institutes of Health; Company of Biologists","keywords":"Biology; Praziquantel; Octopamine (neurotransmitter); Schistosoma mansoni; Neurotransmitter; Drug discovery; Nervous system; Neuroscience; Drug; Pharmacology; Central nervous system; Schistosomiasis; Receptor; Immunology; Bioinformatics; Biochemistry; Serotonin; Helminths","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007066184,0.000198072,0.0001387761,0.0001322121,0.00008134035,0.0002475027,0.0001103949,0.0002092265,0.0005170864],"category_scores_gemma":[0.00003657611,0.00006294338,0.0001424731,0.0001076739,0.0001310237,0.000143493,0.0001059646,0.0002439684,0.000169823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002473902,"about_ca_system_score_gemma":0.0001482575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007659628,"about_ca_topic_score_gemma":0.001389039,"domain_scores_codex":[0.9999822,0.000002445009,0.000001471042,0.000003663392,0.00000432217,0.000005942202],"domain_scores_gemma":[0.9999808,0.000002680677,0.000005614791,0.000001292942,0.000003162027,0.000006358674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009138268,0.00001327359,0.0005074741,0.00006646526,0.000003311743,0.00006718604,0.000006133712,0.0001590816,0.9953309,0.0001977176,0.00005965924,0.003497463],"study_design_scores_gemma":[0.00004788352,0.000992978,0.01728416,0.00003125319,0.00004149004,0.0006997159,0.00007339581,0.004508536,0.9652936,0.0003200195,0.01069262,0.00001430107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770619,0.01623303,0.002666265,0.000509858,0.00003672255,0.00003429024,0.0004870351,0.00006960605,0.002901251],"genre_scores_gemma":[0.9878677,0.008352576,0.001540457,0.0001039953,0.00001261244,0.00001529609,0.0003458898,0.000003938528,0.001757576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007659628,"threshold_uncertainty_score":0.001794934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06256449589100602,"score_gpt":0.267300651511971,"score_spread":0.204736155620965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}