{"id":"W2808989994","doi":"10.1242/dmm.033563","title":"Octopamine signaling in the metazoan pathogen<i>S</i><i>chistosoma mansoni</i>: localization, small-molecule screening and opportunities for drug development","year":2018,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; University of California, San Francisco; National Institutes of Health; Company of Biologists","keywords":"Biology; Praziquantel; Octopamine (neurotransmitter); Schistosoma mansoni; Neurotransmitter; Drug discovery; Nervous system; Neuroscience; Drug; Pharmacology; Central nervous system; Schistosomiasis; Receptor; Immunology; Bioinformatics; Biochemistry; Serotonin; Helminths","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003262384,0.0001909882,0.0001846081,0.0001173823,0.0005401324,0.00004695772,0.0001896125,0.00006183476,0.00005945899],"category_scores_gemma":[0.00002214498,0.0001549592,0.00006869852,0.00007298509,0.00009155819,0.000125195,0.00005582141,0.00009744978,0.00001081809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002016579,"about_ca_system_score_gemma":0.00008089919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003167862,"about_ca_topic_score_gemma":0.00009179881,"domain_scores_codex":[0.9989069,0.0001385036,0.0002894207,0.00030643,0.00005220312,0.0003065219],"domain_scores_gemma":[0.9994445,0.00009476854,0.00008935187,0.0002000179,0.0001183019,0.00005306002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00158176,0.001160819,0.0004377488,0.0002446775,0.0007224956,0.0001587175,0.021374,0.001926828,0.5424993,0.4078315,0.00240539,0.01965675],"study_design_scores_gemma":[0.01031292,0.0009095874,0.002307558,0.001014785,0.001704,0.0002369857,0.02360473,0.0734129,0.5810396,0.1078009,0.1942032,0.003452878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.283878,0.001845843,0.7127264,0.0005027045,0.0001769281,0.0004640095,0.0001284246,0.00004814679,0.0002295931],"genre_scores_gemma":[0.9926916,0.00004176731,0.003672473,0.001914141,0.00003263859,0.0002370003,0.0004750556,0.00002464616,0.0009106598],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7090539,"threshold_uncertainty_score":0.6319053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06256449589100602,"score_gpt":0.267300651511971,"score_spread":0.204736155620965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}