{"id":"W2808990415","doi":"10.1093/neuonc/noy059.149","title":"DIPG-56. PRECLINICAL STUDIES OF DIANHYDROGALACTITOL (VAL-083) IN DIPG, AS SINGLE AGENT OR AS A COMBINATION WITH RADIATION OR AZD1775","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada)","funders":"","keywords":"Temozolomide; Cancer research; DNA repair; Methyltransferase; Cell cycle; Cell cycle checkpoint; DNA damage; Topoisomerase; In vivo; Chemistry; Cancer; Glioma; Biology; DNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000223073,0.0009578989,0.0005759617,0.0004211182,0.0002003641,0.0003368235,0.0005076663,0.0005450392,0.002296332],"category_scores_gemma":[0.0001083253,0.0002135118,0.0004377505,0.0004343116,0.0003628219,0.000335128,0.0001705466,0.001857344,0.0007562789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004759434,"about_ca_system_score_gemma":0.0006856593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001272225,"about_ca_topic_score_gemma":0.002608249,"domain_scores_codex":[0.9998788,0.00001893556,0.000006878113,0.00002638507,0.00002337913,0.00004567303],"domain_scores_gemma":[0.9999068,0.00000705033,0.00001571046,0.00001122046,0.00000804892,0.00005112978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01080705,0.009294068,0.000823873,0.0009440756,0.0001587654,0.0003700722,0.000119046,0.001648165,0.9209293,0.0007561108,0.003223035,0.05092657],"study_design_scores_gemma":[0.005035535,0.1336242,0.01018332,0.00008203818,0.0004080667,0.001381946,0.0001232499,0.001796721,0.8051914,0.0004003567,0.04172018,0.00005303354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764661,0.009581726,0.00158138,0.000515183,0.0002740865,0.0008287431,0.003239023,0.0003674181,0.007146413],"genre_scores_gemma":[0.9805934,0.00675492,0.002276598,0.0003079975,0.00003806674,0.0005239498,0.004369114,0.00004619651,0.005089633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002296332,"threshold_uncertainty_score":0.007681966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07938375954229857,"score_gpt":0.401233425569901,"score_spread":0.3218496660276025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}