{"id":"W2808991402","doi":"10.1093/neuonc/noy059.634","title":"QOL-53. METFORMIN RESULTS IN HIPPOCAMPAL REMODELING AND IMPROVED MEMORY ENCODING IN PAEDIATRIC BRAIN TUMOR SURVIVORS TREATED WITH CRANIAL RADIATION: A PILOT RANDOMIZED CONTROLLED CROSSOVER STUDY","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Hippocampal formation; Medicine; Placebo; Crossover study; Metformin; Brain size; Internal medicine; Anesthesia; Neuroscience; Psychology; Pathology; Magnetic resonance imaging; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00124089,0.001333476,0.002761804,0.0004853339,0.0004514881,0.0007587745,0.0007133411,0.001432153,0.006667352],"category_scores_gemma":[0.001303516,0.0005478828,0.001723452,0.000435772,0.0008279091,0.0007508458,0.0003809462,0.001975953,0.0005708013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004797015,"about_ca_system_score_gemma":0.001031246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001034083,"about_ca_topic_score_gemma":0.002007539,"domain_scores_codex":[0.9994565,0.0002240809,0.00006184177,0.0001123421,0.00005019585,0.000095118],"domain_scores_gemma":[0.9992597,0.000151317,0.0001796772,0.00007916999,0.00006368061,0.0002665033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9419001,0.03460923,0.0009689271,0.0007349399,0.001031427,0.00006795426,0.00006467536,0.0001389937,0.004922927,0.00006030114,0.0004178167,0.01508263],"study_design_scores_gemma":[0.7005563,0.2915494,0.005374596,0.00004592756,0.0006663981,0.00003683519,0.00004214469,0.0002596322,0.0008505054,0.00006017704,0.0005384582,0.0000196593],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937686,0.001185848,0.000281595,0.0001664551,0.0001638692,0.003372175,0.0005994997,0.00006715867,0.0003947944],"genre_scores_gemma":[0.983381,0.001681018,0.00252418,0.0005270854,0.0002152207,0.009383048,0.0006267908,0.00002320899,0.001638399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006667352,"threshold_uncertainty_score":0.02230448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01816303726408535,"score_gpt":0.2934704724841516,"score_spread":0.2753074352200663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}