{"id":"W2809103371","doi":"10.1093/neuonc/noy059.012","title":"ATRT-13. CANCER PREDISPOSITION AMONG CHILDREN WITH RHABDOID TUMORS: A SINGLE-CENTRE RETROSPECTIVE REVIEW","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Children's Hospital of Eastern Ontario; Hospital for Sick Children; University of Ottawa","funders":"","keywords":"SMARCB1; Germline; Genetic testing; Medicine; Atypical teratoid rhabdoid tumor; Family history; Referral; Germline mutation; Retrospective cohort study; Genetic predisposition; Cancer; Medical genetics; Pediatrics; Oncology; Mutation; Internal medicine; Genetics; Biology; Family medicine; Gene; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189721,0.000222809,0.0003129152,0.00002943038,0.0001187301,0.00001585129,0.0001867878,0.0001810007,0.0001394109],"category_scores_gemma":[0.00009217091,0.0001902073,0.00009043737,0.0001536616,0.0002667776,0.000007935097,0.00009075779,0.0001806769,0.000018935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001672508,"about_ca_system_score_gemma":0.0002521928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001191647,"about_ca_topic_score_gemma":0.0009347482,"domain_scores_codex":[0.9985084,0.0001374077,0.0002594268,0.0005923871,0.0001671661,0.0003351888],"domain_scores_gemma":[0.9990273,0.00001432686,0.0002172468,0.0003760163,0.0002520868,0.0001130774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003597552,0.0002801367,0.05742025,0.0001374007,0.0001715454,0.00001932644,0.000177449,0.00005590817,0.8939054,0.00001165271,0.03084405,0.0166171],"study_design_scores_gemma":[0.006811032,0.01813482,0.1058948,0.003227763,0.0009309613,0.0008395438,0.0001338738,0.0008735705,0.7287309,0.0001110273,0.1323996,0.001912251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910718,0.003769055,0.000231147,0.0008951133,0.0002653337,0.000613575,0.00004757663,0.00004996789,0.003056459],"genre_scores_gemma":[0.9929909,0.00227342,0.000288733,0.002739637,0.001311975,0.00008567332,0.0001149674,0.00004753832,0.0001471297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1651746,"threshold_uncertainty_score":0.7756429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008607573678507962,"score_gpt":0.261476409942161,"score_spread":0.2528688362636531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}