{"id":"W2809145153","doi":"10.1080/19420862.2018.1489633","title":"Antigen recognition by single-domain antibodies: structural latitudes and constraints","year":2018,"lang":"en","type":"review","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; National Research Council Canada","funders":"National Research Council Canada","keywords":"Paratope; Single-domain antibody; Epitope; Antibody; Antigen; Computational biology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000591694,0.0005822323,0.0007754365,0.001172963,0.0001704924,0.0008141692,0.0008808912,0.0009898117,0.00132323],"category_scores_gemma":[0.0005017639,0.000255692,0.0002911873,0.0010488,0.000637567,0.001040555,0.0004573526,0.001194584,0.0008236938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000595141,"about_ca_system_score_gemma":0.0007051028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007652616,"about_ca_topic_score_gemma":0.0007748515,"domain_scores_codex":[0.9998287,0.00002894475,0.00001801777,0.00003997645,0.00006515937,0.00001911329],"domain_scores_gemma":[0.9997426,0.0001306796,0.00004145882,0.00001010682,0.00005560107,0.00001945867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009974994,0.00007074855,0.0006429813,0.01752989,0.0001165778,0.0004406989,0.0001298408,0.001146933,0.0210551,0.01503339,0.009127049,0.9346072],"study_design_scores_gemma":[0.00001724022,0.0001815805,0.001852712,0.001855265,0.0001237181,0.002623234,0.00008477763,0.0003725267,0.006785197,0.004874991,0.9812046,0.00002405414],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006620679,0.9970531,0.0004231859,0.000205694,0.00007829197,0.000004745033,0.00001096586,0.000006407919,0.001555535],"genre_scores_gemma":[0.005295191,0.9928969,0.0005106553,0.0002349566,0.0001229358,0.00001226481,0.00003303612,0.000001688874,0.0008923819],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00132323,"threshold_uncertainty_score":0.004426599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1011218756918359,"score_gpt":0.3791820976101544,"score_spread":0.2780602219183185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}