{"id":"W2809164252","doi":"10.1016/j.micpath.2018.06.029","title":"Dipeptidylpeptidase IV of Streptococcus suis degrades the porcine antimicrobial peptide PR-39 and neutralizes its biological properties","year":2018,"lang":"en","type":"article","venue":"Microbial Pathogenesis","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Fonds de Recherche du Québec - Santé; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Streptococcus suis; Microbiology; Proteases; Protease; Biology; Serine protease; Antimicrobial peptides; Antimicrobial; Peptide; Subtilisin; Virulence; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002799901,0.000560261,0.0003195873,0.0002118161,0.0001190133,0.0003089416,0.0001821793,0.0003232808,0.00133408],"category_scores_gemma":[0.0002933902,0.0001293663,0.0003408329,0.0001057913,0.0002811427,0.0002231937,0.0002737593,0.0004160251,0.0005376811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001778921,"about_ca_system_score_gemma":0.0002244656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002944306,"about_ca_topic_score_gemma":0.0001649651,"domain_scores_codex":[0.999788,0.00004945326,0.0000152075,0.00003415343,0.00004821986,0.00006485753],"domain_scores_gemma":[0.9998398,0.00002920118,0.00004918364,0.00001568336,0.0000208289,0.00004524389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002748517,0.00002432005,0.0006146856,0.00003977611,0.000009331915,0.0002474405,0.0000165557,0.00005062531,0.9922512,0.00009228444,0.00004323622,0.006335625],"study_design_scores_gemma":[0.00004497843,0.002124722,0.01009818,0.0000131829,0.00002074963,0.002786582,0.00007775728,0.0004953452,0.9797623,0.0001923685,0.004375785,0.000008091698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897747,0.004584602,0.002828175,0.0001667328,0.00006256567,0.00002766771,0.0001322552,0.00003849959,0.002384834],"genre_scores_gemma":[0.9951397,0.000958587,0.0013237,0.00007689343,0.0000211195,0.000008980887,0.0003236162,0.00001027455,0.002137074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00133408,"threshold_uncertainty_score":0.004462898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04783594541015257,"score_gpt":0.2715154755618712,"score_spread":0.2236795301517187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}