{"id":"W2809164252","doi":"10.1016/j.micpath.2018.06.029","title":"Dipeptidylpeptidase IV of Streptococcus suis degrades the porcine antimicrobial peptide PR-39 and neutralizes its biological properties","year":2018,"lang":"en","type":"article","venue":"Microbial Pathogenesis","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Fonds de Recherche du Québec - Santé; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Streptococcus suis; Microbiology; Proteases; Protease; Biology; Serine protease; Antimicrobial peptides; Antimicrobial; Peptide; Subtilisin; Virulence; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001773515,0.0003610917,0.0005373041,0.0001349745,0.0003385611,0.00004589696,0.0001390541,0.0001801483,0.0002665781],"category_scores_gemma":[0.0001107774,0.0002058175,0.0002313311,0.0003379208,0.0007834845,0.00008735986,0.0001418489,0.0001353789,0.00005998402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004338848,"about_ca_system_score_gemma":0.00008068559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002139053,"about_ca_topic_score_gemma":0.0001067256,"domain_scores_codex":[0.9983101,0.0001293917,0.0004925393,0.0005074787,0.0001287823,0.000431669],"domain_scores_gemma":[0.9989069,0.00006821722,0.0001728908,0.0004162726,0.0002835793,0.0001521841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002747433,0.0003648238,0.2239783,0.00007256964,0.0001509154,0.00002208576,0.0001936696,0.000001019077,0.7719733,0.00003530403,0.0008823024,0.002051003],"study_design_scores_gemma":[0.001563808,0.001000991,0.4044102,0.0002014487,0.0002531481,0.0001841601,0.0001067782,0.00001470904,0.5899472,0.000007389347,0.002094594,0.0002155864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968356,0.0005326896,0.00001787997,0.0005904838,0.0001689913,0.001316229,0.0001695581,0.00008953407,0.000278981],"genre_scores_gemma":[0.9977811,0.0001727551,0.0004104566,0.0002841572,0.000420862,0.0000830576,0.00004337196,0.00003654893,0.0007677005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1820261,"threshold_uncertainty_score":0.8392996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04783594541015257,"score_gpt":0.2715154755618712,"score_spread":0.2236795301517187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}