{"id":"W2809193491","doi":"10.1038/s41588-018-0152-6","title":"Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence","year":2018,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1418,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; NIH Clinical Center; National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; Syddansk Universitet; National Institute of Mental Health; Institute for Molecular Bioscience, University Of Queensland; University of Galway; Medical Research Council; National Institute on Drug Abuse; Biotechnology and Biological Sciences Research Council; Stanley Center for Psychiatric Research, Broad Institute; Pfizer; University of California, Los Angeles; National Institutes of Health; National Institute on Aging; National University of Ireland; National Institute on Alcohol Abuse and Alcoholism; Centre for Cognitive Ageing and Cognitive Epidemiology; Yale University; Karolinska Institutet; Queensland Brain Institute; H. Lundbeck A/S; Johns Hopkins University; Universitetet i Oslo; Universitetet i Bergen; National Center for Research Resources; National and Kapodistrian University of Athens; University of Crete; Imperial College London; University of Toronto; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Broad Institute; Directorate for Biological Sciences; Northwell Health; Trinity College Dublin; Erasmus Universitair Medisch Centrum Rotterdam; University of Oregon; King's College London; Virginia Commonwealth University; Helsingin Yliopisto; Haukeland Universitetssjukehus; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; University of Southern California; National Science Foundation; University of Minnesota; Massachusetts General Hospital; Department of Psychology and Neuroscience, Duke University; Eli Lilly and Company; University of North Carolina at Chapel Hill; Brigham and Women's Hospital","keywords":"Biology; Genome-wide association study; Computational biology; Genetic association; Genetics; Meta-analysis; Association (psychology); Genome; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0030516,0.001161497,0.00207859,0.001979308,0.0002057567,0.001016186,0.001173751,0.001237629,0.001810196],"category_scores_gemma":[0.005224897,0.0004036735,0.00208533,0.0030453,0.0004234113,0.0006387432,0.0008627882,0.00139605,0.0003567568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003957741,"about_ca_system_score_gemma":0.001485447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002912464,"about_ca_topic_score_gemma":0.006761273,"domain_scores_codex":[0.9991897,0.0002299926,0.0001566064,0.0002218135,0.0001547355,0.00004710681],"domain_scores_gemma":[0.9969007,0.00235665,0.000294355,0.0001226371,0.0002470679,0.00007863024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001385107,0.00009133966,0.06744464,0.03575041,0.02978598,0.001215026,0.0002011746,0.0009321985,0.001497513,0.003678397,0.02526898,0.8327492],"study_design_scores_gemma":[0.0009156723,0.000660887,0.3003426,0.03025902,0.129289,0.00834722,0.0005770706,0.0009593015,0.002317027,0.02718589,0.4987989,0.0003474005],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002938878,0.9936287,0.0008628098,0.001165599,0.0002678775,0.000009218557,0.0004751697,0.00001844085,0.0006332578],"genre_scores_gemma":[0.02783128,0.9673734,0.001752415,0.001109673,0.0006081744,0.00002608889,0.0009045957,0.00001007694,0.0003843575],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0030516,"threshold_uncertainty_score":0.01613855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05448888801207556,"score_gpt":0.3406124845852443,"score_spread":0.2861235965731688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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