{"id":"W2809198755","doi":"10.1093/neuonc/noy059.481","title":"MBRS-36. IDENTIFICATION OF TWO PROTEIN-SIGNALING STATES DELINEATING TRANSCRIPTIONALLY HETEROGENEOUS HUMAN MEDULLOBLASTOMA","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medulloblastoma; Biology; Signal transduction; Phosphoprotein; Phosphorylation; Cancer research; Cell cycle; Apoptosis; DNA damage; Cell biology; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004584142,0.0002211032,0.0003015717,0.00009232263,0.0002379949,0.00001831152,0.000286039,0.0001688392,0.00003456985],"category_scores_gemma":[0.0002192942,0.000229056,0.000128751,0.0001255055,0.0003677667,0.000006407638,0.00009878232,0.0001354844,0.00001773107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004102349,"about_ca_system_score_gemma":0.0001273453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002530484,"about_ca_topic_score_gemma":0.0001747609,"domain_scores_codex":[0.9979317,0.0002645432,0.0007147461,0.0005369369,0.0002126879,0.0003394362],"domain_scores_gemma":[0.998714,0.00005188932,0.0003542137,0.000336125,0.0004616987,0.00008202863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001344145,0.0001176111,0.0003159173,0.00003237503,0.0000808616,0.00001188076,0.0003899285,0.0005517469,0.9958112,0.00008890827,0.0001503938,0.002314808],"study_design_scores_gemma":[0.0007635571,0.001825228,0.0001066417,0.00001974098,0.00003899357,0.00004715088,0.00009820432,0.0003553992,0.9842366,0.0002728019,0.01204631,0.0001893593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911628,0.0002049074,0.007394794,0.0001932122,0.0002848676,0.0003927293,0.00003646202,0.00003938016,0.0002908075],"genre_scores_gemma":[0.9970341,0.00001932129,0.001604827,0.0004036525,0.0006451419,0.00008716409,0.0001012761,0.00004447395,0.00006007447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01189591,"threshold_uncertainty_score":0.9340633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0242251518447045,"score_gpt":0.3111506951164242,"score_spread":0.2869255432717197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}