{"id":"W2809201980","doi":"10.1038/s41586-018-0290-0","title":"A multiprotein supercomplex controlling oncogenic signalling in lymphoma","year":2018,"lang":"en","type":"article","venue":"Nature","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":403,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto General Hospital; University of Toronto; BC Cancer Agency","funders":"National Cancer Institute; National Institutes of Health","keywords":"Ibrutinib; breakpoint cluster region; Bruton's tyrosine kinase; Cancer research; Syk; B-cell receptor; Biology; Signal transducing adaptor protein; B cell; Signal transduction; Cell biology; Tyrosine kinase; Chronic lymphocytic leukemia; Leukemia; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000405316,0.0002541266,0.0002862672,0.0005563232,0.0007938013,0.00151714,0.0003791481,0.0004392536,0.003468976],"category_scores_gemma":[0.000542954,0.0002467953,0.0002423204,0.0002805045,0.0004534253,0.000895843,0.000951722,0.0005824568,0.001039704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008573613,"about_ca_system_score_gemma":0.0003077055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002864157,"about_ca_topic_score_gemma":0.0002256079,"domain_scores_codex":[0.9997165,0.0000499592,0.0000159827,0.00007123301,0.0000733859,0.00007293894],"domain_scores_gemma":[0.9995766,0.00006624904,0.0001035026,0.00004894911,0.00005370581,0.0001509308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004631986,0.00006731688,0.002080209,0.0001109343,0.00002686967,0.000281486,0.000139698,0.0008120614,0.9720258,0.006543839,0.001922161,0.0155265],"study_design_scores_gemma":[0.00010844,0.000684664,0.03145706,0.00008942881,0.00007303764,0.001683696,0.0007338573,0.01732016,0.8771936,0.01126938,0.05930731,0.00007938701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9577669,0.01104978,0.01328629,0.002246273,0.0003861157,0.00007823291,0.0004414239,0.0004688058,0.01427613],"genre_scores_gemma":[0.991569,0.00134086,0.003001626,0.0002311748,0.00007800419,0.00002304938,0.0003780303,0.00006205138,0.003316261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003468976,"threshold_uncertainty_score":0.01160491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0147503203548242,"score_gpt":0.2877688406829173,"score_spread":0.2730185203280931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}